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Blood Pressure Management in Stroke Following Endovascular Treatment

NCT04484350 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2023-11-07

No results posted yet for this study

Summary

The aim of DETECT is to prove the feasibility of a multicenter phase III trial testing the hypothesis that intensive blood pressure control immediately after successful endovascular stroke thrombectomy can improve patient outcomes. Patients with stroke who have ongoing high blood pressure after successful clot retrieval will be included. Participants will be randomly placed (like flipping a coin) in one of two groups. There will be a 50% chance of each patient being placed to either group. The first group will be allowed to have a higher blood pressure range that is consistent with current recommendations. The second group will be given medications to bring their blood pressure down into a normal range. These blood pressure targets will be maintained for 48 hours. We will collect patient brain images and levels of stroke disability up to 90 days after their clot retrieval.

Conditions

  • Stroke, Acute
  • Vessels; Occlusion
  • Blood Pressure
  • Endovascular Thrombectomy
  • Mechanical Thrombectomy

Interventions

DRUG

Labetalol

10 - 20 mg IV q15 minutes PRN until systolic BP below target (max 300 mg per 24 hours)

DRUG

Hydralazine

10 - 20 mg IV bolus q20 min until systolic BP below target (max 240 mg per 24 hours)

DRUG

Enalapril

1.25 - 2.5 mg IV bolus and then q6h PRN.

Sponsors & Collaborators

  • Hamilton Health Sciences Corporation

    lead OTHER

Principal Investigators

  • Aristeidis H Katsanos, MD · Hamilton General Hospital, Hamilton Health Sciences

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-23
Primary Completion
2023-02-04
Completion
2023-05-04

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04484350 on ClinicalTrials.gov