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Laser Treatment of Moderate to Severe Acne Vulgaris

NCT04466527 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 4

Last updated 2026-06-01

Study results available
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Summary

The goal of this clinical trial is to learn if fractional ablative laser can treat active acne vulgaris in adults 18 to 40 years old with moderate to severe acne vulgaris.

The main questions it aims to answer are:

Does ablative fractional carbon dioxide treatment effectively treat moderate to severe active nodular acne vulgaris?

Does ablative fractional carbon dioxide treatment effectively treat moderate to severe active nodular acne vulgaris over a short time frame?

Is non-selective laser useful in treating inflammatory skin disease?

How does the microbiome change after laser treatment?

Participants will...

* Receive up to 3 laser treatments
* Attend a baseline visit and follow-up visits post-treatment where participants will receive a clinical assessment, facial swab, and facial-imaging

Conditions

  • Acne Vulgaris

Interventions

DEVICE

Laser Intervention

Subjects receive laser treatment.

Sponsors & Collaborators

Principal Investigators

  • Dieter Manstein, MD, PhD · Massachusetts General Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-09
Primary Completion
2022-07-27
Completion
2022-07-27
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04466527 on ClinicalTrials.gov