Coronavirus Disease 2019 (COVID-19) During Pregnancy: Prevalence of Seroconversion, Effect on Maternal and Perinatal Outcomes and Risk of Vertical Transmission (COVID-MAP)

Summary

The objectives of this proposal are to: 1) determine the rate of SARS-CoV-2 seroconversion in unselected pregnant women in Hong Kong; 2) determine the rate of SARS-CoV-2 infection in women presenting with miscarriage and stillbirth; 3) follow the pregnancy course and perinatal outcome of confirmed COVID-19-infected pregnant cases; 4) determine the risk and characteristics of vertical transmission; and 5) evaluate the placental barrier, immune response and fetal damage in vertical transmission of SARS-CoV-2. A series of longitudinal and cross-sectional observational studies, and a laboratory-based study will be conducted to fulfil the 5 objectives.

Conditions

• COVID-19

Interventions

OTHER

Non Intervention

It's an observational study, no intervention involves.

Sponsors & Collaborators

• Peking University First Hospital

  collaborator OTHER

• Hospital Universitario de Torrejón

  collaborator UNKNOWN

• Queen Mary Hospital, Hong Kong

  collaborator OTHER

• Pamela Youde Nethersole Eastern Hospital

  collaborator OTHER

• Queen Elizabeth Hospital, Hong Kong

  collaborator OTHER

• United Christian Hospital

  collaborator OTHER

• Kwong Wah Hospital

  collaborator OTHER

• Princess Margaret Hospital, Hong Kong

  collaborator OTHER_GOV

• Tuen Mun Hospital

  collaborator OTHER_GOV

• Chinese University of Hong Kong

  lead OTHER

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-05-01

Primary Completion

2024-04-30

Completion

2024-12-31

Countries

• China
• Hong Kong
• Spain

Study Locations