Mechanistic Study of Ocrevus
NCT04459988 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35
Last updated 2024-05-31
Summary
The purpose of this study is to investigate the immune cell and other factor changes with Ocrevus in Multiple Sclerosis (MS) patients. Researchers will recruit 35 participants for this study. Patients will be enrolled from the Multiple Sclerosis Center at the University of Michigan Health System in Ann Arbor. The goal of the study is to understand the role of regulatory B cell, T cell and other factors in mediating the therapeutic effects of Ocrevus.
Conditions
Interventions
- DRUG
-
Ocrelizumab
Description Needed
Sponsors & Collaborators
- lead OTHER
Principal Investigators
-
Yang Mao-Draayer, MD/PHD · University of Michigan
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2020-07-01
- Primary Completion
- 2022-10-25
- Completion
- 2022-10-25
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administration In Participants With Multiple Sclerosis
NCT03972306 ·Status: COMPLETED ·Phase: PHASE1
-
Effects of Ocrelizumab Treatment on Immune Cells in Lymph Nodes in Multiple Sclerosis
NCT06495593 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE4
-
A Study to Provide Complementary Efficacy, Safety and Patient Reported Outcomes Data in Participants With Active Relapsing Forms of Multiple Sclerosis (MS) in a Pragmatic Setting
NCT03589105 ·Status: COMPLETED ·Phase: PHASE4
-
Upper Extremity Function in Multiple Sclerosis Patients With Advanced Disability Treated With Ocrevus
NCT03562975 ·Status: COMPLETED
-
Investigation of the Effect of Ocrelizumab on Peripheral Lymphocyte Immunophenotypes with Suppressive Capacity in MS
NCT04874597 ·Status: ACTIVE_NOT_RECRUITING
-
A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
NCT02861014 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of the Efficacy and Safety of Ocrelizumab in Patients With Relapsing-Remitting Multiple Sclerosis
NCT00676715 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of Ocrelizumab on Neuroinflammation in Multiple Sclerosis as Measured by 11C-PBR28 MR-PET Imaging of Microglia Activation
NCT04230174 ·Status: COMPLETED ·Phase: PHASE4
-
Ocrelizumab Effects on the Metabolome in MS
NCT03873389 ·Status: COMPLETED
-
Impact of Ocrelizumab on Cerebrospinal Fluid Biomarkers at Multiple Sclerosis Onset
NCT04466150 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
Estimating Prevalence of COVID-19 Infection and SARS-CoV-2 Antibodies in MS Patients
NCT04682548 ·Status: COMPLETED
-
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis
NCT04544449 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Impact of Annual Versus Biannual Infusions of Ocrelizumab in Patients With Active MS,After 2 Years of Initial Treatment, on Freedom From Radiological Disease Activity at Two Years: a Multicenter Randomized Controlled Non-inferiority Trial
NCT05999604 ·Status: RECRUITING ·Phase: PHASE3
-
Mechanism of Action of Ocrelizumab in Multiple Sclerosis
NCT03344094 ·Status: COMPLETED
-
Effects of Ocrevus in Relapsing Multiple Sclerosis
NCT04387734 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
Investigating the Effect of Ocrelizumab in African Americans and Caucasians With Relapsing Multiple Sclerosis
NCT04458688 ·Status: RECRUITING
-
A Study to Compare Efficacy, Pharmacokinetics, Pharmacodynamics and Safety of CT-P53 and Ocrevus in Patients With Relapsing-remitting Multiple Sclerosis
NCT05906992 ·Status: RECRUITING ·Phase: PHASE3
-
Non-interventional Study of Ocrelizumab in Participants With Relapsing or Primary Progressive Multiple Sclerosis
NCT03593590 ·Status: COMPLETED
-
Symptom Burden in Patients Treated With Ocrelizumab for Multiple Sclerosis
NCT04855617 ·Status: COMPLETED
-
A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis
NCT03523858 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
NCT00001248 ·Status: RECRUITING
-
Ocrelizumab Effects on Physiological and Cognitive Changes in Multiple Sclerosis
NCT03025269 ·Status: COMPLETED
-
A Systems Approach to Understanding Disease Processes in Multiple Sclerosis
NCT05081700 ·Status: COMPLETED
-
A Study to Assess the Effects of MK0812 on Disease Activity in Patients With Relapsing-Remitting Multiple Sclerosis as Measured by Magnetic Resonance Imaging (MRI)(0812-003)(COMPLETED)
NCT00239655 ·Status: TERMINATED ·Phase: PHASE2
-
Immune Regulation in Multiple Sclerosis: The Effect of Glatiramer Acetate on MicroRNA Expression in Antigen-Presenting Cells
NCT01993004 ·Status: COMPLETED