High Flow Nasal Cannula in Pediatric Patients After Cardiothoracic Surgery

Summary

High flow nasal cannula(HFNC) ventilation can provide such effects as wash-out effect of the carbon dioxide inside the anatomical dead space,some level of continuous airway pressure and humidified oxygen gases.

Therefore because of its physiological benefits, it has been reported that HFNC can reduce "treatment failure" after extubation in pediatric patients like preterm babies,or infants who suffer from bronchitis.

However there is no evidence showing that HFNC can reduce "treatment failure" after extubation in pediatric patients after cardiothoracic surgery.

This multi-center randomized controlled trial (RCT) involving pediatric patients after cardiothoracic surgery will be conducted to determine whether HFNC,compared with conventional oxygen therapy,after extubation can reduce the rate of"escalation of care due to treatment failure".

Conditions

• Pediatric Patients After Cardiothoracic Surgery

Interventions

DEVICE

high flow nasal cannula therapy

Once extubation has taken place, the child will be placed either on conventional oxygen therapy or high flow nasal cannulae according to randomization

DEVICE

low flow nasal cannula therapy

Once extubation has taken place, the child will be placed either on conventional oxygen therapy or high flow nasal cannulae according to randomization

Sponsors & Collaborators

• Osaka Women's and Children's Hospital

  collaborator UNKNOWN

• Hyogo Prefectural Kobe Children's Hospital

  collaborator OTHER

• Osaka City General Hospital

  collaborator OTHER

• Aichi Children's Health and Medical Center

  collaborator UNKNOWN

• National Center for Child Health and Development

  collaborator UNKNOWN

• Osaka University

  lead OTHER

Principal Investigators

• Takeshi Yoshida, MDPhD · Department of Anesthesiology and Intensive Care Medicine, Osaka University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Max Age

2 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-08-11

Primary Completion

2024-02-20

Completion

2024-06-30

Countries

• Japan

Study Locations