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Single vs Multi-fraction SRS Patients on Immunotherapy

NCT04427228 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL

Last updated 2023-08-28

No results posted yet for this study

Summary

This study is meant to compare different surgical approaches to brain cancer.

Conditions

Interventions

RADIATION

Radiosurgery Single Treatment

Frameless single-fraction SRS. One large treatment done on each brain tumor. 20 Gy for GTVs (or resection cavity CTVs) \< 2 cm, and 18 Gy for GTVs (or resection cavity CTVs) between 2-3 cm in the single-fraction.

RADIATION

Radiosurgery Three Treatments

Multi-fraction SRS. Three small doses done on each brain tumor. 27 Gy in 3 fractions in the multi-fraction group

Sponsors & Collaborators

  • University of Chicago

    lead OTHER

Principal Investigators

  • Steven Chmura, MD · University of Chicago

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-06-29
Primary Completion
2022-12-12
Completion
2022-12-12
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04427228 on ClinicalTrials.gov