The Effect of Nonverbal Vocalisations on Pain Tolerance

Summary

Humans produce non-verbal vocalizations (shouting, growling, screaming), laughter, ...) in various contexts that are likely to perform biological functions.

and important social issues. Yet despite their importance in the human vocal repertoire, the mechanisms and functions of non-verbal vocalizations remain little studied and poorly understood including in humans. In this context, the investigators wish to examine how the production of vocalizations non-verbal communication influences pain tolerance in healthy adults.

Conditions

• Healthy

Interventions

BEHAVIORAL

Cold pressor task (CPT)

The cold pressor test is among the most common and established methods for studying human reactions to pain and pain tolerance. Participants submerge a hand in cold water (approx. 5°C) and are asked to keep their hand submerged for as long as can (until the sensation is intolerable), up to a maximum of 5 min. The procedure is safe because the hand is removed before adverse effects can occur. The participant will be given a break of 5 min in between trials, and will interchange hands between trials. During this break hand may to be place in warm water (25-35°C) for up to 4 min to normalise hand temperature, which will be measured before and after each trial using a digital thermometer held firmly in the palm of the hand. Each participant will complete no more than three trials (conditions) in a randomised order.

BEHAVIORAL

Acoustic Recordings

During the experiment, the vocalizations produced will be systematically recorded for each participant and an analysis of the acoustic structure of these vocalizations will be carried out.

DIAGNOSTIC_TEST

Index measurement NOL™

Four sensors placed non-invasively on one finger. of the participants will be able to calculate a dozen physiological parameters converts in real time into a pain index called NOL (for Nociception Level Index).

DIAGNOSTIC_TEST

Video pupillometry

This technique is based on the observation of the dilatation of the pupil during the perception of a nociceptive stimulus in test persons.

Sponsors & Collaborators

• Laboratoire ENES-CNPS (Université Lyon/Saint Etienne)

  collaborator UNKNOWN

• Centre Hospitalier Universitaire de Saint Etienne

  lead OTHER

Principal Investigators

• Roland PEYRON, MD · CHU SAINT-ETIENNE

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-05-11

Primary Completion

2026-05-31

Completion

2026-05-31

Countries

• France

Study Locations