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The Precise Selection of Stent Diameter for Portal Hypertension Patients With TIPS

NCT04421118 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2023-02-16

No results posted yet for this study

Summary

The precise planning of TIPS, especially individual selection of stent diameter, is a hot and difficult topic in the field. We have successfully developed a non-invasive technology to evaluate hepatic venous pressure gradient and portal pressure gradient based on three-dimensional modeling and fluid dynamics simulation. We propose the concept of virtual stent-based portal pressure gradient for the first time. With invasive pressure as reference, the accuracy of virtual stent-based portal pressure gradient will be evaluated in levels of animal experiments and clinical trials. The predictive value of virtual stent-based portal pressure gradient for individualized selection of TIPS stent diameter will be further assessed.

Conditions

  • Compensated Advanced Chronic Liver Disease
  • Portal Hypertension

Interventions

OTHER

a non-invasive technology to evaluate hepatic venous pressure gradient and portal pressure gradient

a non-invasive technology to evaluate hepatic venous pressure gradient and portal pressure gradient based on three-dimensional modeling and fluid dynamics simulation

Sponsors & Collaborators

  • LanZhou University

    collaborator OTHER

  • First Affiliated Hospital of Zhejiang University

    lead OTHER

Principal Investigators

  • Jun-hui Sun, MD,PH.D · First Affiliated Hospital of Zhejiang University

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-11
Primary Completion
2023-12-20
Completion
2024-12-20

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04421118 on ClinicalTrials.gov