COVID-19 Pandemic and Worldwide Organ Procurement

Summary

End-stage organ failure is estimated to affect more than 4 to 6 million persons worldwide. In 2018, transplant systems across the globe enabled around 150,000 patients to benefit from a kidney, heart, lung, liver, or other solid organ, a number that was far less than the demand. According to data from the World Health Organization, more than 1,500,000 persons live with a transplanted organ worldwide. In the US, approximately 40,000 patients receive an organ transplant every year, but 120,000 still remain waitlisted for transplantation today, with 7,600 dying annually while waiting for an organ transplant. A similar lack of organs and high death rates on the waiting list affect patients in Europe and many other countries.

As nations adjust to new realities driven by the coronavirus (COVID-19) outbreak, many health care providers, institutions and patients are concerned about the potential impact that COVID-19 will have on organ donation and transplantation. One concern is that transplant recipients may have a greater susceptibility to infection and greater viral burden. A second concern is that hospitals will lack the resources in terms of staff and equipment to care for recipients after transplantation, who often require intensive care and multispecialty management.

Because of the overwhelming healthcare system burden, a dramatic negative effect on worldwide organ donation and transplantation is anticipated, but has not been measured. Our objective was to quantify the worldwide impact of COVID-19 pandemic on organ donation and transplantation and consequences for waitlisted patients.

Conditions

• COVID-19

Sponsors & Collaborators

• Agence de La Biomédecine

  collaborator OTHER_GOV

• Eurotransplant

  collaborator UNKNOWN

• United Network for Organ Sharing

  collaborator UNKNOWN

• Deutsche Stiftung Organtransplantation

  collaborator UNKNOWN

• Centro Nazionale Trapianti

  collaborator UNKNOWN

• Brazilian Organ Transplant Association

  collaborator UNKNOWN

• The Canadian Association of Transplantation

  collaborator UNKNOWN

• Scandiatransplant

  collaborator UNKNOWN

• Nederlandse Transplantatie Vereniging

  collaborator UNKNOWN

• Austrotransplant

  collaborator UNKNOWN

• Centro Nacional de Trasplantes

  collaborator UNKNOWN

• Instituto Nacional de Donación y Trasplante de Células, Tejidos y Órganos

  collaborator UNKNOWN

• Donor Network of Croatia

  collaborator UNKNOWN

• Instituto Nacional Central Único Coordinador de Ablación e Implante

  collaborator OTHER_GOV

• Corporación Nacional de Trasplantes de Chile

  collaborator UNKNOWN

• Australian Organ and Tissue Donation and Transplantation Authority

  collaborator UNKNOWN

• Organización Nacional de Trasplantes

  collaborator UNKNOWN

• Autoridade Para Services de Sangue e Transplantacáo

  collaborator UNKNOWN

• Paris Translational Research Center for Organ Transplantation

  lead OTHER

Principal Investigators

• Alexandre Loupy · Paris Translational Research Center for Organ Transplantation

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-02-01

Primary Completion

2022-02-28

Completion

2022-02-28

Countries

• France

Study Locations