Trial Outcomes & Findings for Screen to Save 2: Rural Cancer Screening Educational Intervention (NCT NCT04414306)
NCT ID: NCT04414306
Last Updated: 2026-02-02
Results Overview
A pre-test and post-test are conducted with participants to assess changes in knowledge related to key learning outcomes expected from the educational intervention (assessed via 14 true/false and multiple-choice questions, reported as a percent change in points). An increased % change in points represents increased knowledge of each survey question and a value of 0 indicates knowledge did not change (a negative value would indicate decreased knowledge). % change is a unique number that was calculated as the difference between the % answering correctly after the intervention minus the % correct before the intervention; it is representative of the entire data set and not calculated on an individual participant level. P values (\<0.05) are based on chi-square tests. Each row represents a unique survey question evaluating the topic listed in the row title.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
205 participants
Primary outcome timeframe
pre-test administered immediately before educational intervention; post-test administered immediately after the educational intervention on day 1.
Results posted on
2026-02-02
Participant Flow
Participant milestones
| Measure |
Experimental Arm 1
Participants who meet eligibility criteria will be able to enroll and participate on-line, with some participating in online or telephone survey follow-up.
Online educational video and website module: Participants will receive online education via a video and website. Key messages will include information on risk factors, prevention, screening recommendations, and screening options pertaining to colorectal cancer. Some participants will be asked to participate in three and/or six-month follow-up surveys administered online or by telephone.
|
|---|---|
|
Overall Study
STARTED
|
205
|
|
Overall Study
COMPLETED
|
205
|
|
Overall Study
NOT COMPLETED
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Screen to Save 2: Rural Cancer Screening Educational Intervention
Baseline characteristics by cohort
| Measure |
Experimental Arm 1
n=205 Participants
Participants who meet eligibility criteria will be able to enroll and participate on-line, with some participating in online or telephone survey follow-up.
Online educational video and website module: Participants will receive online education via a video and website. Key messages will include information on risk factors, prevention, screening recommendations, and screening options pertaining to colorectal cancer. Some participants will be asked to participate in three and/or six-month follow-up surveys administered online or by telephone.
|
|---|---|
|
Age, Customized
<55
|
40 Participants
n=41 Participants
|
|
Age, Customized
55-59
|
39 Participants
n=41 Participants
|
|
Age, Customized
60-64
|
57 Participants
n=41 Participants
|
|
Age, Customized
65-69
|
39 Participants
n=41 Participants
|
|
Age, Customized
70-74
|
30 Participants
n=41 Participants
|
|
Sex/Gender, Customized
Woman
|
165 Participants
n=41 Participants
|
|
Sex/Gender, Customized
Man
|
40 Participants
n=41 Participants
|
|
Sex/Gender, Customized
Non-binary/gender nonconforming
|
0 Participants
n=41 Participants
|
|
Race/Ethnicity, Customized
Non-Hispanic White
|
202 Participants
n=41 Participants
|
|
Race/Ethnicity, Customized
Other
|
2 Participants
n=41 Participants
|
|
Race/Ethnicity, Customized
Declined to Answer
|
1 Participants
n=41 Participants
|
|
Region of Enrollment
United States
|
205 participants
n=41 Participants
|
|
Educational attainment
High school diploma/GED or less
|
11 Participants
n=41 Participants
|
|
Educational attainment
Some college
|
39 Participants
n=41 Participants
|
|
Educational attainment
College graduate
|
155 Participants
n=41 Participants
|
|
Number of Forms of Insurance
None
|
2 Participants
n=41 Participants
|
|
Number of Forms of Insurance
Single
|
163 Participants
n=41 Participants
|
|
Number of Forms of Insurance
Two or more
|
40 Participants
n=41 Participants
|
|
Type of insurance
Current or former employer
|
112 Participants
n=41 Participants
|
|
Type of insurance
Individual plan
|
21 Participants
n=41 Participants
|
|
Type of insurance
Military
|
8 Participants
n=41 Participants
|
|
Type of insurance
Medicare
|
75 Participants
n=41 Participants
|
|
Type of insurance
Medicaid
|
12 Participants
n=41 Participants
|
|
Type of insurance
Other
|
18 Participants
n=41 Participants
|
|
Ever screened for CRC
Yes
|
170 Participants
n=41 Participants
|
|
Ever screened for CRC
No
|
30 Participants
n=41 Participants
|
|
Ever screened for CRC
I don't know
|
5 Participants
n=41 Participants
|
|
Number of methods of CRC screening
Single method
|
122 Participants
n=41 Participants
|
|
Number of methods of CRC screening
Two or more methods
|
48 Participants
n=41 Participants
|
|
Number of methods of CRC screening
Never screened/don't know
|
35 Participants
n=41 Participants
|
|
Type of CRC screening method
Colonoscopy
|
158 Participants
n=41 Participants
|
|
Type of CRC screening method
Sigmoidoscopy
|
20 Participants
n=41 Participants
|
|
Type of CRC screening method
FIT/FOBT
|
25 Participants
n=41 Participants
|
|
Type of CRC screening method
DNA (Cologuard)
|
21 Participants
n=41 Participants
|
|
Type of CRC screening method
Computed Tomography
|
1 Participants
n=41 Participants
|
|
History of polyps
Yes
|
71 Participants
n=41 Participants
|
|
History of polyps
No
|
115 Participants
n=41 Participants
|
|
History of polyps
Data Missing
|
19 Participants
n=41 Participants
|
|
History of CRC
Yes
|
5 Participants
n=41 Participants
|
|
History of CRC
No
|
200 Participants
n=41 Participants
|
|
History of CRC in any first-degree relatives
Yes
|
42 Participants
n=41 Participants
|
|
History of CRC in any first-degree relatives
No
|
163 Participants
n=41 Participants
|
|
History of CRC in any distant relatives
Yes
|
32 Participants
n=41 Participants
|
|
History of CRC in any distant relatives
No
|
173 Participants
n=41 Participants
|
PRIMARY outcome
Timeframe: pre-test administered immediately before educational intervention; post-test administered immediately after the educational intervention on day 1.A pre-test and post-test are conducted with participants to assess changes in knowledge related to key learning outcomes expected from the educational intervention (assessed via 14 true/false and multiple-choice questions, reported as a percent change in points). An increased % change in points represents increased knowledge of each survey question and a value of 0 indicates knowledge did not change (a negative value would indicate decreased knowledge). % change is a unique number that was calculated as the difference between the % answering correctly after the intervention minus the % correct before the intervention; it is representative of the entire data set and not calculated on an individual participant level. P values (\<0.05) are based on chi-square tests. Each row represents a unique survey question evaluating the topic listed in the row title.
Outcome measures
| Measure |
Experimental Arm 1
n=205 Participants
Participants who meet eligibility criteria will be able to enroll and participate on-line, with some participating in online or telephone survey follow-up.
Online educational video and website module: Participants will receive online education via a video and website. Key messages will include information on risk factors, prevention, screening recommendations, and screening options pertaining to colorectal cancer. Some participants will be asked to participate in three and/or six-month follow-up surveys administered online or by telephone.
|
Experimental Arm 1 Post-Education
Participants who meet eligibility criteria will be able to enroll and participate on-line, with some participating in online or telephone survey follow-up.
Online educational video and website module: Participants will receive online education via a video and website. Key messages will include information on risk factors, prevention, screening recommendations, and screening options pertaining to colorectal cancer. Some participants will be asked to participate in three and/or six-month follow-up surveys administered online or by telephone.
|
|---|---|---|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Early detection improves outcome
|
-.5 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Role of polyps in the development of CRC
|
0 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
CRC can be asymptomatic
|
1 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Where CRC starts in the body
|
2 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
What is Lynch Syndrome
|
13 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Purpose of colonoscopy
|
1 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Important not to skip screening if asymptomatic
|
-.5 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
What the stool test checks for
|
5 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Recommended age to start colonoscopy
|
16 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Recommended age to start FIT/FOBT
|
24 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Family history of CRC
|
.5 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Poor diet
|
4 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Red and processed meats
|
3 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Being overweight or obese
|
7 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Tobacco use
|
11 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Lack of physical activity
|
18 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Heavy drinking
|
19 Percent Change
|
—
|
|
Change in Correct Responses Regarding Knowledge Related to Colorectal Cancer Risk, Prevention, and Screening
Role of physical activity in reducing CRC risk
|
18 Percent Change
|
—
|
PRIMARY outcome
Timeframe: pre-test administered immediately before educational intervention; post-test administered immediately after educational intervention on day 1A pre-test and post-test are conducted to assess behavioral intention related to five prevention and screening behaviors (assessed via 5 questions on a 5-point Likert scale: strongly agree (5), agree, unsure, disagree, strongly disagree(1). The values reported represent the difference between pre-intervention and post-intervention scores, calculated as a unique number for the total responding participants (not calculated individually). A positive change represents increased intent. Each row represents a unique survey question evaluating the topic listed in the row title.
Outcome measures
| Measure |
Experimental Arm 1
n=205 Participants
Participants who meet eligibility criteria will be able to enroll and participate on-line, with some participating in online or telephone survey follow-up.
Online educational video and website module: Participants will receive online education via a video and website. Key messages will include information on risk factors, prevention, screening recommendations, and screening options pertaining to colorectal cancer. Some participants will be asked to participate in three and/or six-month follow-up surveys administered online or by telephone.
|
Experimental Arm 1 Post-Education
n=205 Participants
Participants who meet eligibility criteria will be able to enroll and participate on-line, with some participating in online or telephone survey follow-up.
Online educational video and website module: Participants will receive online education via a video and website. Key messages will include information on risk factors, prevention, screening recommendations, and screening options pertaining to colorectal cancer. Some participants will be asked to participate in three and/or six-month follow-up surveys administered online or by telephone.
|
|---|---|---|
|
Change in Colorectal Cancer Screening and Other Risk Behavior Intentions
Get CRC screening
|
4.54 score on a scale
Standard Deviation .68
|
4.66 score on a scale
Standard Deviation .59
|
|
Change in Colorectal Cancer Screening and Other Risk Behavior Intentions
Talk to a healthcare provider about CRC screening
|
4.39 score on a scale
Standard Deviation .81
|
4.5 score on a scale
Standard Deviation .68
|
|
Change in Colorectal Cancer Screening and Other Risk Behavior Intentions
Eat healthier diet
|
4.08 score on a scale
Standard Deviation .78
|
4.22 score on a scale
Standard Deviation .72
|
|
Change in Colorectal Cancer Screening and Other Risk Behavior Intentions
Increase physical activity
|
4 score on a scale
Standard Deviation .8
|
4.2 score on a scale
Standard Deviation .71
|
|
Change in Colorectal Cancer Screening and Other Risk Behavior Intentions
Talk about CRC with family or friends
|
3.89 score on a scale
Standard Deviation .9
|
4.15 score on a scale
Standard Deviation .84
|
Adverse Events
Experimental Arm 1
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place