MedTrace Logo

Anti-inflammatory Effect of Curcumin, Homotaurine, Vitamin D3 on Human Vitreous in Patients With Diabetic Retinopathy

NCT04378972 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2020-05-07

No results posted yet for this study

Summary

Dosage of pro-inflammatory cytokines and soluble mediators (TNFα, IL6, IL2 and PDGF-AB) performed on 25 vitreous biopsies taken from patients with diabetic retinopathy and treated with increasing doses of curcumin (0.5uM and 1uM), with or without homotaurine (100uM) and vitamin D3 (50nM).

Conditions

Interventions

OTHER

curcumin, homotaurine, vitamin D3

ELISA tests on supernatants of 25 vitreous biopsies incubated with bioactive molecules at 37 ° C for 20 h. The concentration of soluble mediators was calculated from a calibration curve.

OTHER

control

ELISA tests on supernatants of 25 vitreous biopsies. The concentration of soluble mediators was calculated from a calibration curve.

Sponsors & Collaborators

  • Ospedale Humanitas Gradenigo, Torino

    collaborator UNKNOWN

  • Cliniche Humanitas Gavazzeni

    collaborator OTHER

  • Consorzio Sannio Tech

    collaborator OTHER

  • University of Roma La Sapienza

    collaborator OTHER

  • FB VISION, Ascoli Piceno, Italy

    collaborator UNKNOWN

  • University of Molise

    lead OTHER

Principal Investigators

  • Ciro Costagliola, Full Professor · University of Molise

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-09-16
Primary Completion
2019-11-16
Completion
2019-12-02

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04378972 on ClinicalTrials.gov