Quality of Life and Long-term Outcomes After Hospitalization for COVID-19

Summary

The present study aims to assess the determinants of health-related quality of life and long-term outcomes among survivors of hospitalization for Covid-19 in Brazil. The investigators will conduct a multicenter prospective cohort study nested in randomized clinical trials (coalition Covid-19 Brazil initiative) originally designed to assess the effects of specific Covid-19 treatments. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed up for a period of one year by means of structured telephone interviews. The primary outcome is one-year health-related quality of life assessed by the EQ-5D-3L. Secondary outcomes include all-cause mortality, rehospitalizations, return to work or study, physical functional status assessed by the Lawton \& Brody Instrumental Activities of Daily Living Scale, dyspnea assessed by the modified medical research council dyspnea scale, need of long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, and symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-revised.

Conditions

• Quality of Life
• Long-term Outcomes
• Coronavirus Infection

Interventions

OTHER

COVID-19 Severity

Disease severity characterized by the highest six-level ordinal scale during the hospital stay, which consists of the following categories: a score of 1 indicated not hospitalized; 2, hospitalized and not receiving supplemental oxygen; 3, hospitalized and receiving supplemental oxygen; 4, hospitalized and receiving oxygen supplementation administered by a high-flow nasal cannula or noninvasive ventilation; 5, hospitalized and receiving mechanical ventilation; and 6, death

Sponsors & Collaborators

• Hospital Israelita Albert Einstein

  collaborator OTHER

• Hospital Sirio-Libanes

  collaborator OTHER

• Hospital do Coracao

  collaborator OTHER

• Hospital Alemão Oswaldo Cruz

  collaborator OTHER

• Beneficência Portuguesa de São Paulo

  collaborator OTHER

• Brazilian Clinical Research Institute

  collaborator OTHER

• Brazilian Research In Intensive Care Network

  collaborator NETWORK

• Hospital Moinhos de Vento

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-07-15

Primary Completion

2022-03-11

Completion

2022-03-11

Countries

• Brazil

Study Locations