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Efficacy of Pragmatic Same-day COVID-19 Ring Prophylaxis for Adult Individuals Exposed to SARS-CoV-2 in Switzerland

NCT04364022 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 326

Last updated 2021-04-12

No results posted yet for this study

Summary

A study to assess, in a two-arm open-label cluster randomized clinical trial, the efficacy of a 5-day course of LPV/r treatment in preventing COVID-19 in asymptomatic individuals exposed to a SARS-CoV-2 documented index patient, compared to surveillance alone.

Conditions

  • Prevention of COVID-19

Interventions

DRUG

Lopinavir/ritonavir

2x 200mg/50mg, twice daily for 5 days (bid, PO)

Sponsors & Collaborators

  • Calmy Alexandra

    lead OTHER

Principal Investigators

  • Alexandra Calmy, Prof · University Hospital, Geneva

  • Niklaus Labhardt, Prof · Universitätsspital Basel

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-23
Primary Completion
2021-03-24
Completion
2021-03-24

Countries

  • Brazil
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04364022 on ClinicalTrials.gov