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Simplifying Treatment and Monitoring for HIV (STREAM HIV)

NCT04341779 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 539

Last updated 2026-02-19

Study results available
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Summary

This study seeks to determine the clinical efficacy and cost effectiveness of implementing an integrated model for HIV monitoring using point of care (POC) tenofovir (TFV) adherence testing and POC viral load (VL) monitoring in improving ART adherence, maintaining durable VL suppression, and improving retention in care among HIV-positive individuals initiating first-line tenofovir disoproxil fumarate (TDF)-based ART in South Africa.

Conditions

Interventions

COMBINATION_PRODUCT

Point-of-care viral load testing and tenofovir adherence testing

Point-of-care testing of HIV viral load and tenofovir, and providing same day results to participants

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • Centre for the AIDS Programme of Research in South Africa

    collaborator NETWORK

  • University of Washington

    lead OTHER

Principal Investigators

  • Paul Drain, MD, MPH · University of Washington

  • Nigel Garett, MBBS, PHD · Centre for the AIDS Programme of Research in South Africa (CAPRISA)

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-04
Primary Completion
2025-06-30
Completion
2026-12-31

Countries

  • South Africa

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04341779 on ClinicalTrials.gov