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Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure

NCT04320498 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 41

Last updated 2022-04-07

No results posted yet for this study

Summary

Autologous PRP currently has many uses in surgical and medical therapy. Compared with other regenerative therapies, PRP is easy-to-prepare, low-cost, and does not require complex equipment. The use of autologous PRP avoids immunological side effects. Data is lacking on the use of PRP in the treatment of anal fissure. This study evaluated PRP as an alternative medical treatment for chronic anal fissures.

Conditions

  • Anal Fissure Chronic
  • PRP

Interventions

BIOLOGICAL

prp injection

PRP was injected locally in the anal fissure area and glyceryl trinitrate was administered twice daily in the perianal region as in the control group.

DRUG

Anrecta

self-administered topical glyceryl trinitrate (anrecta), in the perianal area twice a day

BEHAVIORAL

sitz bath

participants were told to take a hot water sitz bath once a day

DIETARY_SUPPLEMENT

nutrition regulation

The study participants were told to eat a fiber-rich diet and to drink least 2 liters of water daily

Sponsors & Collaborators

  • Istanbul Medipol University Hospital

    collaborator OTHER

  • KTO Karatay University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2019-12-14
Completion
2021-01-02

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04320498 on ClinicalTrials.gov