Trial Outcomes & Findings for The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia (NCT NCT04255745)
NCT ID: NCT04255745
Last Updated: 2026-06-02
Results Overview
change in systolic and diastolic blood pressure
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
77 participants
Primary outcome timeframe
baseline, 12 weeks
Results posted on
2026-06-02
Participant Flow
Recruitment dates: 01/27/2020 through September 2022. Recruitment was temporarily paused from 03/06/2020 through July 2020 due to the COVID pandemic and university mandated closures of research. Recruitment resumed in August 2020
After enrollment, study eligibility was confirmed via hand grip strength assessment. Clinically meaningful weakness will determine study eligibility is defined as a grip strength \<30kg in men and \<20kg in women. Adults who do not meet the cutoff for low sex-specific grip strength were ineligible to continue.
Participant milestones
| Measure |
Intervention
60 Intervention group will receive 12 weeks of supervised resistance training following the American Heart Association and American College of Sports Medicine guidelines for older adults. Exercises will include a mixture of upper-body and lower body strength exercises. Training load will be determined based on initial 1-repetition maximum tests (1-RM). Initial exercise load will start off at low resistance (40-50% 1RM) with more frequent repetitions per exercise, and will gradually increase weight load and intensity over the exercise training period.
progressive resistance training: Individual, tailored, progressive muscle strength and function intervention
|
Assessment-only Control
30 Assessment-only control group will be mailed (standard or electronic) NIH/National Institutes on Aging (NIA) Go4Life® educational materials once a month for 3 months. Exercise logs documenting weekly exercise activities, duration, time and effort will be requested to be sent back.
|
|---|---|---|
|
Overall Study
STARTED
|
50
|
27
|
|
Overall Study
Number who initiated the intervention
|
45
|
26
|
|
Overall Study
COMPLETED
|
40
|
21
|
|
Overall Study
NOT COMPLETED
|
10
|
6
|
Reasons for withdrawal
| Measure |
Intervention
60 Intervention group will receive 12 weeks of supervised resistance training following the American Heart Association and American College of Sports Medicine guidelines for older adults. Exercises will include a mixture of upper-body and lower body strength exercises. Training load will be determined based on initial 1-repetition maximum tests (1-RM). Initial exercise load will start off at low resistance (40-50% 1RM) with more frequent repetitions per exercise, and will gradually increase weight load and intensity over the exercise training period.
progressive resistance training: Individual, tailored, progressive muscle strength and function intervention
|
Assessment-only Control
30 Assessment-only control group will be mailed (standard or electronic) NIH/National Institutes on Aging (NIA) Go4Life® educational materials once a month for 3 months. Exercise logs documenting weekly exercise activities, duration, time and effort will be requested to be sent back.
|
|---|---|---|
|
Overall Study
Withdrawal by Subject
|
10
|
6
|
Baseline Characteristics
The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia
Baseline characteristics by cohort
| Measure |
Assessment-only Control
n=21 Participants
21 Assessment-only control group will be mailed (standard or electronic) NIH/National Institutes on Aging (NIA) Go4Life® educational materials once a month for 3 months. Exercise logs documenting weekly exercise activities, duration, time and effort will be requested to be sent back.
|
Intervention
n=50 Participants
50 Intervention group will receive 12 weeks of supervised resistance training following the American Heart Association and American College of Sports Medicine guidelines for older adults. Exercises will include a mixture of upper-body and lower body strength exercises. Training load will be determined based on initial 1-repetition maximum tests (1-RM). Initial exercise load will start off at low resistance (40-50% 1RM) with more frequent repetitions per exercise, and will gradually increase weight load and intensity over the exercise training period.
progressive resistance training: Individual, tailored, progressive muscle strength and function intervention
|
Total
n=71 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
68.4 years
STANDARD_DEVIATION 6.30 • n=9 Participants
|
70.8 years
STANDARD_DEVIATION 6.18 • n=27 Participants
|
70.1 years
STANDARD_DEVIATION 6.26 • n=267 Participants
|
|
Sex: Female, Male
Female
|
15 Participants
n=9 Participants
|
39 Participants
n=27 Participants
|
54 Participants
n=267 Participants
|
|
Sex: Female, Male
Male
|
6 Participants
n=9 Participants
|
11 Participants
n=27 Participants
|
17 Participants
n=267 Participants
|
|
Race/Ethnicity, Customized
Black
|
7 participants
n=9 Participants
|
24 participants
n=27 Participants
|
31 participants
n=267 Participants
|
|
Race/Ethnicity, Customized
Not Black
|
14 participants
n=9 Participants
|
26 participants
n=27 Participants
|
40 participants
n=267 Participants
|
|
Region of Enrollment
United States
|
21 participants
n=9 Participants
|
50 participants
n=27 Participants
|
71 participants
n=267 Participants
|
|
body mass index
|
29.6 kg per meters squared
STANDARD_DEVIATION 7.52 • n=9 Participants
|
30.8 kg per meters squared
STANDARD_DEVIATION 8.55 • n=27 Participants
|
30.4 kg per meters squared
STANDARD_DEVIATION 8.22 • n=267 Participants
|
|
grip strength
|
20.1 kg
STANDARD_DEVIATION 4.41 • n=9 Participants
|
18.3 kg
STANDARD_DEVIATION 4.50 • n=27 Participants
|
18.8 kg
STANDARD_DEVIATION 4.51 • n=267 Participants
|
PRIMARY outcome
Timeframe: baseline, 12 weeksPopulation: patients were hypertensive and taking blood pressure lowering medication. Prescription data was collected at baseline but not during follow up.
change in systolic and diastolic blood pressure
Outcome measures
| Measure |
Assessment-only Control
n=21 Participants
21 Assessment-only control group will be mailed (standard or electronic) NIH/National Institutes on Aging (NIA) Go4Life® educational materials once a month for 3 months. Exercise logs documenting weekly exercise activities, duration, time and effort will be requested to be sent back.
|
Intervention
n=50 Participants
50 Intervention group will receive 12 weeks of supervised resistance training following the American Heart Association and American College of Sports Medicine guidelines for older adults. Exercises will include a mixture of upper-body and lower body strength exercises. Training load will be determined based on initial 1-repetition maximum tests (1-RM). Initial exercise load will start off at low resistance (40-50% 1RM) with more frequent repetitions per exercise, and will gradually increase weight load and intensity over the exercise training period.
progressive resistance training: Individual, tailored, progressive muscle strength and function intervention
|
|---|---|---|
|
Change in Blood Pressure
DBP_12 weeks
|
81.5 mmHg
Standard Deviation 11.4
|
78.4 mmHg
Standard Deviation 10.9
|
|
Change in Blood Pressure
SBP_12-weeks
|
125.0 mmHg
Standard Deviation 19.1
|
127.5 mmHg
Standard Deviation 19.4
|
|
Change in Blood Pressure
SBP_Baseline
|
125.5 mmHg
Standard Deviation 21.4
|
131.4 mmHg
Standard Deviation 19.6
|
|
Change in Blood Pressure
DBP_Baseline
|
81.2 mmHg
Standard Deviation 12.6
|
81.6 mmHg
Standard Deviation 12.3
|
Adverse Events
Assessment-only Control
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Intervention
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Deepika Laddu, Associate Professor
Northwestern University
Phone: 312-503-4827
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place