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Buprenorphine Plus Baclofen to Increase Analgesia in Healthy Volunteers

NCT04251819 · Status: TERMINATED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2026-01-07

Study results available
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Summary

To determine if baclofen will enhance buprenorphine analgesia for acute pain in healthy volunteers.

Conditions

  • Acute Pain
  • Analgesia

Interventions

DRUG

Placebos

Participants will receive placebo in combination with 0.3 mg of buprenorphine to examine analgesia in acute pain tasks.

DRUG

Baclofen 5 mg

Participants will receive 5mg of baclofen in combination with 0.3 mg of buprenorphine to examine analgesia in acute pain tasks.

DRUG

Baclofen 10mg

Participants will receive 10mg of baclofen in combination with 0.3 mg of buprenorphine to examine analgesia in acute pain tasks.

Sponsors & Collaborators

  • University of Alabama at Birmingham

    lead OTHER

Principal Investigators

  • Karen L Cropsey, Psy.D. · University of Alabama at Birmingham

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-01-21
Primary Completion
2024-06-15
Completion
2024-06-15
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04251819 on ClinicalTrials.gov