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Tissue and Clinical Characterisation of Temporomandibular Joint Diseases

NCT04251455 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2020-02-05

No results posted yet for this study

Summary

Temporomandibular joint (TMJ) diseases or dysfunctions affects many patients. Surgical treatment is planned when non-invasive interventions have failed. Still, much is not known regarding aetiology of TMJ diseases and how and why the disease develops over time. The study aims to investigate synovial tissue, synovial fluid and clinical characteristics for patients with TMJ diseases or dysfunctions designated for surgery. Patient samples and clinical variables will be analysed in relation to TMJ diagnosis and related to surgical outcome. The study is a cohort observational study.

Conditions

  • Temporomandibular Joint Disorders
  • Temporomandibular Arthritis
  • Temporomandibular Joint Disc Displacement
  • Temporomandibular Joint Osteoarthritis

Interventions

PROCEDURE

Arthroscopy or discectomy with sampling of synovial fluid and synovial tissue

Arthroscopic lysis and lavage: performed under general anaesthesia. Before initiation of arthroscopy synovial fluid was sampled with a push-and-pull method. The TMJ was investigated with an arthroscope during irrigation with sterile saline solution. Adhesions were addressed with a coblator. Synovial tissue biopsies were taken from the posterior attachment of the disc. Discectomy without replacement: performed under general anaesthesia. Before initiation of surgery, synovial fluid was sampled as above described. During surgery synovial tissue biopsies were taken as described above.

Sponsors & Collaborators

  • University of Bergen

    collaborator OTHER

  • University of Oslo

    collaborator OTHER

  • Karolinska Institutet

    lead OTHER

Principal Investigators

  • Bodil Lund, Professor · Karolinska Institutet, University of Bergen

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-01-14
Primary Completion
2018-06-05
Completion
2018-06-05

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04251455 on ClinicalTrials.gov