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Expression of Inflammasomes in HCV Patients

NCT04244383 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2020-01-28

No results posted yet for this study

Summary

Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a minority of patients can clear the virus spontaneously during acute infection. Elimination of HCV during acute infection correlates with a rapid induction of innate and a delayed induction of adaptive immune responses. The majority of patients is unable to clear the virus and develops viral persistence despite the ongoing innate and adaptive immune response. The virus usually develops several strategies to escape these immune responses.

Conditions

  • Hepatitis C

Interventions

DIAGNOSTIC_TEST

interleukin IL-1beta and interleukin IL-18

pro-inflammatory cytokines measured in the serum

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Asmaa Salah El-dien Gaber, lecturer · participator in the research

  • Mohamed Ahmed Medhat, lecturer · participator in the research

  • Sara Fergany Abd El-hamid, student · participator in the research

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-01-31
Primary Completion
2020-06-30
Completion
2020-07-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04244383 on ClinicalTrials.gov