Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease

Summary

Research question: Can multiparametric renal Magnetic Resonance Imaging (MRI) provide structural and functional assessment of the kidneys to deliver prognostic information and guide treatment options in chronic kidney disease (CKD)?

Aims and objectives:

1. To establish a multiparametric renal MRI protocol in CKD cohorts.
2. To use multiparametric MRI to characterise people with and without CKD progression.
3. To compare multiparametric renal MRI with 'gold-standard' renal biopsy to determine pathological processes of CKD progression that are detectable by MRI.

Conditions

• Chronic Kidney Diseases

Interventions

DIAGNOSTIC_TEST

Multiparametric renal MRI

Localiser scans; Kidney volume; Longitudinal (T1) relaxation time mapping; Diffusion weighted imaging (DWI); Phase Contrast MRI; Arterial spin labelling (ASL); Blood Oxygen Level Dependent (BOLD) mapping

Sponsors & Collaborators

• University of Nottingham

  collaborator OTHER

• Queen Elizabeth University Hospital Glasgow

  collaborator UNKNOWN

• Royal Infirmary of Edinburgh

  collaborator OTHER

• University of Edinburgh

  collaborator OTHER

• Newcastle University

  collaborator OTHER

• Newcastle-upon-Tyne Hospitals NHS Trust

  collaborator OTHER

• University of Leeds

  collaborator OTHER

• The Leeds Teaching Hospitals NHS Trust

  collaborator OTHER

• Sheffield Teaching Hospitals NHS Foundation Trust

  collaborator OTHER

• University of Sheffield

  collaborator OTHER

• Northern Care Alliance NHS Foundation Trust

  collaborator OTHER

• University College, London

  collaborator OTHER

• University of Cambridge

  collaborator OTHER

• Cambridge University Hospitals NHS Foundation Trust

  collaborator OTHER

• University Hospitals of Derby and Burton NHS Foundation Trust

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-06-01

Primary Completion

2027-02-28

Completion

2033-02-28

Countries

• United Kingdom

Study Locations