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RASCALS: Rapid Assay for Sick Children With Acute Lung Infection Study

NCT04233268 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2021-10-20

No results posted yet for this study

Summary

Lower Respiratory Tract infections are a common cause of admission to the intensive care unit. Children routinely receive antibiotics until the tests confirm whether the infection is bacterial or viral. The exclusion of bacterial infection may take 48 hours or longer for culture tests on biological samples to be completed. In many cases, the results may be inconclusive or negative if the patient has already received antibiotics prior to the sample being taken.

A rapid assay to detect the most likely cause of infection could improve the speed with which antibiotic therapy is rationalised or curtailed.

This study aims to assess whether a new genetic testing kit which can identify the presence of bacteria and viruses within hours rather than days is a feasible tool in improving antibiotic prescribing and rationalisation of therapy in critically ill children with suspected lower respiratory tract infection.

Conditions

  • Lower Respiratory Tract Infection
  • Ventilator Associated Pneumonia
  • COVID19

Interventions

DIAGNOSTIC_TEST

Rapid Pathogen Detection

Rapid assays for pathogen detection on bronchoalveolar lavage fluid

Sponsors & Collaborators

  • Cambridge University Hospitals NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Nazima Pathan, FRCPCH PhD · Cambridge University Hospitals NHS Foundation Trust

Eligibility

Min Age
0 Months
Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-06-06
Primary Completion
2023-02-28
Completion
2025-02-28

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04233268 on ClinicalTrials.gov