Trial Outcomes & Findings for Validity and Reliability of the 6-minute Walk Test Over a Distance of 6 Metres in People With Multiple Sclerosis (NCT NCT04228328)

NCT ID: NCT04228328

Last Updated: 2026-02-04

Results Overview

The patient walk for 6 minutes back and forth in a 6-meter hallway turning around cones.

Recruitment status

COMPLETED

Target enrollment

21 participants

Primary outcome timeframe

First test day

Results posted on

2026-02-04

Participant Flow

On 32 patients pre-screened, 4 could not be reached by phone, 1 left for another country, 1 suffered too much from heath, 4 did not met inclusion criteria and 1 finally withdrew : 21 were enrolled

Participant milestones

Participant milestones
Measure	Test Group Participants walked for 6 minutes on a 6-m walkway, did the 360 Degree Turn Test, walked for 6 minutes on a 30-m walkway and again a 6 m walkway.
Overall Study STARTED	21
Overall Study COMPLETED	21
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Validity and Reliability of the 6-minute Walk Test Over a Distance of 6 Metres in People With Multiple Sclerosis

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Test Group n=21 Participants Participants walked for 6 minutes on a 6-m walkway, did the 360 Degree Turn Test, walked for 6 minutes on a 30-m walkway and again a 6-m walkway.
Age, Continuous	55 years STANDARD_DEVIATION 10.6 • n=41 Participants
Sex: Female, Male Female	17 Participants n=41 Participants
Sex: Female, Male Male	4 Participants n=41 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=41 Participants
Race (NIH/OMB) Asian	0 Participants n=41 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=41 Participants
Race (NIH/OMB) Black or African American	0 Participants n=41 Participants
Race (NIH/OMB) White	20 Participants n=41 Participants
Race (NIH/OMB) More than one race	0 Participants n=41 Participants
Race (NIH/OMB) Unknown or Not Reported	1 Participants n=41 Participants
Region of Enrollment Switzerland	21 participants n=41 Participants
Height	168 cm STANDARD_DEVIATION 5.6 • n=41 Participants
Weight	64 kg STANDARD_DEVIATION 10 • n=41 Participants
Type of MS Relapsing-remitting	10 Participants n=41 Participants
Type of MS Secondary progressive	10 Participants n=41 Participants
Type of MS Primary progressive	1 Participants n=41 Participants
Expanded Disability Status Scale	4.75 units on a scale n=41 Participants
Disease duration	19 years n=41 Participants
Assistive device None	9 Participants n=41 Participants
Assistive device 1 crutch	2 Participants n=41 Participants
Assistive device 2 walking sticks	4 Participants n=41 Participants
Assistive device 2 crutches	1 Participants n=41 Participants
Assistive device Walker	5 Participants n=41 Participants
Time since last relapse	60 month n=41 Participants
Medication None	10 Participants n=41 Participants
Medication Interferon	2 Participants n=41 Participants
Medication Fingolimod	1 Participants n=41 Participants
Medication Ocrelizumab	8 Participants n=41 Participants
Visual Analogue Scale for Fatigue	2 units on a scale n=41 Participants
Regular physical activity	90 min n=41 Participants

PRIMARY outcome

Timeframe: First test day

The patient walk for 6 minutes back and forth in a 6-meter hallway turning around cones.

Outcome measures

Outcome measures
Measure	Test Group n=21 Participants Participants walked for 6 minutes on a 6 m distance, did the 360 Degree Turn Test, walked for 6 minutes on a 30 m distance and again a 6 m distance.
The 6-minutes Walk Test on 6 Meters Tester measured	215.86 m Standard Deviation 113.8
The 6-minutes Walk Test on 6 Meters Video-verified	221.57 m Standard Deviation 113.8

SECONDARY outcome

Timeframe: First test day

The person must complete a full lap on himself or herself and the execution time is measured

Outcome measures

Outcome measures
Measure	Test Group n=21 Participants Participants walked for 6 minutes on a 6 m distance, did the 360 Degree Turn Test, walked for 6 minutes on a 30 m distance and again a 6 m distance.
360 Degree Turn Test (Time)	6.00 s Standard Deviation 4.11

SECONDARY outcome

Timeframe: First test day

The person must complete a full lap on himself or herself and the number of steps is measured

Outcome measures

Outcome measures
Measure	Test Group n=21 Participants Participants walked for 6 minutes on a 6 m distance, did the 360 Degree Turn Test, walked for 6 minutes on a 30 m distance and again a 6 m distance.
360 Degree Turn Test (Number of Steps)	8.16 number of steps Standard Deviation 3.59

SECONDARY outcome

Timeframe: Second test day

The patient walk for 6 minutes back and forth in a 30-meter hallway turning around cones.

Outcome measures

Outcome measures
Measure	Test Group n=21 Participants Participants walked for 6 minutes on a 6 m distance, did the 360 Degree Turn Test, walked for 6 minutes on a 30 m distance and again a 6 m distance.
6 Minute Walk Test on 30 Meters	295.95 m Standard Deviation 156.54

SECONDARY outcome

Timeframe: Second test day

The patient walk for 6 minutes back and forth in a 6-meter hallway turning around cones.

Outcome measures

Outcome measures
Measure	Test Group n=21 Participants Participants walked for 6 minutes on a 6 m distance, did the 360 Degree Turn Test, walked for 6 minutes on a 30 m distance and again a 6 m distance.
The 6-minutes Walk Test on 6 Meters Tester measured	227.05 s Standard Deviation 123.49
The 6-minutes Walk Test on 6 Meters Video-verified	228.90 s Standard Deviation 122.87

Adverse Events

Test Group

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Pr Kenny Guex, director of thesis

Haute Ecole de Santé Vaud

Phone: +41 21 316 80 46

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place