The Effectiveness and Safety of Resective Epilepsy Surgery for TRE

Summary

A prospective cohort studies to identify clinical seizure control, cognitive changes, and safety in resective epilepsy surgery in patients with TSC-related drug-resistant epilepsy.

Conditions

• Tuberous Sclerosis Complex
• Epilepsy

Interventions

PROCEDURE

Surgery

Resective surgery included lobectomy (partial or total brain lobe resection), tuberectomy (epileptogenic tuber resection), and tuberectomy plus (resection of epileptogenic tuber and perituberal gyri). Tuberectomy was typically performed on the epileptogenic tuber within or near an eloquent area. Lobectomy was performed in patients with large epileptogenic tubers in the brain lobes. Multiple lobectomies, tuberectomies, tuberectomies plus, and lobectomy combined with tuberectomy/tuberectomies plus were further performed in patients with multiple epileptogenic tubers.

Sponsors & Collaborators

• Shenzhen Children's Hospital

  collaborator OTHER_GOV

• Tiantan Hospital, Capital Medical University

  collaborator UNKNOWN

• Peking University People's Hospital

  collaborator OTHER

• Guangdong 999 Brain Hospital

  collaborator OTHER

• Xinqiao Hospital, Amry Medical University

  collaborator UNKNOWN

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• West China Hospital

  collaborator OTHER

• Henan Provincial People's Hospital

  collaborator OTHER

• Shanghai Children's Hospital

  collaborator OTHER

• First Medical Center, PLA General Hospital

  collaborator UNKNOWN

• Fourth Medical Center, PLA General Hospital

  collaborator UNKNOWN

• The First Affiliated Hospital of University of Science and Technology of China

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• First Affiliated Hospital Xi'an Jiaotong University

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• The First Affiliated Hospital of Shanxi Medical University

  collaborator OTHER

• Xuanwu Hospital, Beijing

  collaborator OTHER

• The First Hospital of Jilin University

  collaborator OTHER

• Xiangya Hospital of Central South University

  collaborator OTHER

• Beijing Sanbo Brain Hospital

  collaborator OTHER

• Nanjing Medical University

  collaborator OTHER

• Beijing Children's Hospital

  lead OTHER

Eligibility

Min Age

2 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-12-12

Primary Completion

2027-03-15

Completion

2027-03-15

Countries

• China

Study Locations