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Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch

NCT04197440 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2019-12-17

No results posted yet for this study

Summary

With this experiment, the experimenter wish to create a new model of itch based on the substance BAM8-22 (Bovine Adrenal Medulla), which is found naturally in the human body and which has proved to evoke itch.

Conditions

  • Itch

Interventions

DRUG

BAM8-22 2mg/ml

20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm followed by a prick through the drop

DRUG

BAM8-22 1mg/ml

20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm followed by a prick through the drop

DRUG

BAM8-22 0.5 mg/ml

20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm followed by a prick through the drop

DRUG

Placebo

20 µl of water will be applied to a previously determined area on the volar forearm followed by a prick through the drop

DRUG

BAM8-22 with 1 SPT

20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm followed by 1 prick through the drop

DRUG

BAM8-22 with 5 SPT

20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm followed by 5 prick through the drop

DRUG

BAM8-22 with 25 SPT

20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm followed by 25 prick through the drop

DRUG

BAM8-22 with inactivate cowhage spicules

20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm using inactivate cowhage spicules

Sponsors & Collaborators

  • Aalborg University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-01-15
Primary Completion
2020-05-15
Completion
2020-12-15

Countries

  • Denmark

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04197440 on ClinicalTrials.gov