MedTrace Logo

Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study

NCT04194619 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2026-03-11

No results posted yet for this study

Summary

There are no prospective studies of pregnancies for the diseases studied here in (Heredity Hemorrhagic Telangiectasia, Marfan syndrome or related, primary lower limb lymphedema, superficial arteriovenous malformations, and cerebro-spinal arteriovenous malformations) although complications of these can present life-threatening health problems for the mother and her baby.

The purpose of this National prospective study is to obtain greater insight into obstetrical complications associated with rare maternal vascular genetic disorders in order to improve prevention and to reduce risk of death.

In this context, experts and patient associations consider that there is a need to make real progress in the formulation of recommendations based on scientific data.

Conditions

  • Vascular Anomaly
  • Osler Rendu Disease
  • Marfan Syndrome or Related
  • Lymphedema Primary
  • Arteriovenous Malformations
  • Cerebrospinal; Disorder

Interventions

OTHER

Questionnaire

Interview of women with a rare vascular disease through a phone questionnaire about severe and specific obstetrical complications during and after pregnancy.

Sponsors & Collaborators

  • Hospices Civils de Lyon

    lead OTHER

Principal Investigators

  • Sophie DUPUIS-GIROD, MD · Service de Génétique - Hôpital Femme-Mère-Enfant - HCL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-06
Primary Completion
2027-02-28
Completion
2028-11-30

Countries

  • France

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04194619 on ClinicalTrials.gov