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Signature of the Risk Profile of Mortality in a Hospital Cohort of Patients With Metabolic Diseases

NCT04194372 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 10000

Last updated 2026-05-22

No results posted yet for this study

Summary

Epidemiological studies are usually conducted in the general population in adults without complications or pathology at baseline. The results obtained are therefore often better designed for primary prevention use. The prediction of mortality risk in patients with complications and requiring hospital follow-up is less well known.

The study purpose is to determine a mortality risk profile in a hospital cohort of patients with pathologies associated with metabolic diseases.

Today the "multimaker" scores based on a panel of biomarkers - have significantly improved the discriminating power of prediction models existing in many pathologies. It is no longer a single biomarker that can improve risk prediction but a complete and cross-sectional profile that is sought after. We aim to establish a personalised mortality risk profile by combining clinical and biological parameters including metabolomics, genetics, transcriptomics and epigenomics by high throughput screening of biological samples.

Conditions

  • Metabolic Disease

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • François Pattou, MD,PhD · University Hospital, Lille

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-12-20
Primary Completion
2030-01-31
Completion
2030-01-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04194372 on ClinicalTrials.gov