MedTrace Logo

Safety and Immunogenicity of the Candidate Rabies Vaccine ChAdOx2 RabG

NCT04162600 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2024-11-08

No results posted yet for this study

Summary

This is a first-in-human, open-label, dose escalation, phase I clinical trial to assess the safety and immunogenicity of the candidate ChAdOx2 RabG vaccine in healthy UK volunteers aged 18-65. The vaccine will be administered intramuscularly (IM).

Conditions

  • Rabies

Interventions

BIOLOGICAL

ChAdOx2 RabG

Single dose of ChAdOx2 RabG at different concentrations: 5 x 10\^9 vp, 2.5 x 10\^10 vp, 5 x 10\^10 vp

BIOLOGICAL

Inactivated Rabies Vaccine

A complete pre-exposure prophylactic course of an existing rabies vaccine, ≥2.5 international units.

BIOLOGICAL

ChAdOx2 RabG

Single dose of ChAdOx2 RabG at different concentrations: 5 x 10\^9 vp, 2.5 x 10\^10 vp, 5 x 10\^10 vp

BIOLOGICAL

ChAdOx2 RabG

Single dose of ChAdOx2 RabG at different concentrations: 5 x 10\^9 vp, 2.5 x 10\^10 vp, 5 x 10\^10 vp.

BIOLOGICAL

Inactivated Rabies Vaccine

A complete pre-exposure prophylactic course of an existing rabies vaccine, ≥2.5 international units.

BIOLOGICAL

Inactivated Rabies Vaccine

A complete pre-exposure prophylactic course of an existing rabies vaccine, ≥2.5 international units.

Sponsors & Collaborators

  • University of Oxford

    lead OTHER

Principal Investigators

  • Alexander D Douglas · Jenner Institute

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-01-02
Primary Completion
2024-07-10
Completion
2024-07-10

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04162600 on ClinicalTrials.gov