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OCT and Early Cognitive Impairment in Multiple Sclerosis

NCT04153773 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2019-11-13

No results posted yet for this study

Summary

The aim of this study is to investigate the relationship between cognitive impairment and retinal nerve fiber layer \& ganglion cell inner plexiform layer in MS.

Conditions

Interventions

DIAGNOSTIC_TEST

OCT

The degree of physical disability was assessed by using the Expanded Disability Status Scale (EDSS). The EDSS score ranges from 0 to 10 in 0.5 unit increments that represent higher levels of disability. Neurocognitive functions were evaluated using the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) that includes the following tests: 1. Symbol Digit Modalities Test (SDMT) that is used for assessment of information processing speed. 2. California Verbal Learning Test - 2nd edition (CVLT-II) . 3. Brief Visuospatial Memory Test-Revised (BVMT-R) OCT assessment was performed by spectral domain-optical coherence tomography to assess the retinal nerve fiber layer thickness and macular volume in humans . Each eye for every patient was assessed by measuring the thickness of RNFL and GCC, respecting presence or absence of the previous history of optic neuritis (ON).

Sponsors & Collaborators

  • Mansoura University Hospital

    lead OTHER

Principal Investigators

  • Esmael M Ahmed, MD · Assistant Prof of Neurology

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-08-01
Primary Completion
2019-06-01
Completion
2019-09-01

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04153773 on ClinicalTrials.gov