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The Association Between Calretinin and the Function of Ganglion Cells in Hirschsprung Disease

NCT04149093 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2021-03-17

No results posted yet for this study

Summary

This study aims to compare the outcomes of patients with long segment Hirschsprung disease or total colonic aganglionosis who had negative calretinin staining and positive ganglion cells on the proximal resection margins to those who had both positive findings.

Conditions

  • Hirschsprung Disease
  • Ganglion
  • Hirschsprung Disease, Long-Segment
  • Hypoganglionosis

Interventions

DIAGNOSTIC_TEST

Calretinin staining

A paraffin-embedded hematoxylinphloxin-safran sections will be performed on tissue specimens of proximal resection margins to evaluate the presence or absence of ganglion cells. Immunohistochemistry (IHC) will then be done on paraffin-embedded sections for calretinin staining.

Sponsors & Collaborators

  • St. Justine's Hospital

    lead OTHER

Eligibility

Min Age
0 Years
Max Age
18 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-05-01
Primary Completion
2021-09-01
Completion
2021-12-01

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04149093 on ClinicalTrials.gov