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Comparison of the Effects of Dexmedetomidine and Propofol on the Cardiovascular Autonomic Nervous System During Spinal Anesthesia

NCT04142502 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2022-02-18

No results posted yet for this study

Summary

Spinal anesthesia induces bradycardia and hypotnesion, because itself decreases parasympathetic activity and increases sympathetic activity. These imbalance of autonomic nervous system can be measured by heart rate variability. Propofol and dexmedetomidine, which are used for sedation during spinal anesthesia, also affect autonomic nervous system, but the exact effects are not well known. The purpose of this study is measuring the effects of propofol or dexmedetomidine on autonomic nervous system in spinal anesthesia.

Conditions

  • Spinal Anesthesia
  • Autonomic Nervous System

Interventions

DRUG

Propofol

Propofol as a sedation drug

DRUG

Dexmedetomidin

Dexmedetomidine as a sedation drug

Sponsors & Collaborators

  • Ilsung Pharmaceuticals CO.,LTD.

    collaborator UNKNOWN

  • Ajou University School of Medicine

    lead OTHER

Principal Investigators

  • In Kyong Yi, MD · Ajou University School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-20
Primary Completion
2021-12-30
Completion
2021-12-31

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04142502 on ClinicalTrials.gov