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Age-Related Changes in Sleep-Dependent Emotional Memory

NCT04141722 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2019-10-28

No results posted yet for this study

Summary

Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. In young adults, sleep is widely implicated in emotional processing, including consolidation of emotional memories. Evidence suggests that aging is associated with changes in emotion, including a positive memory bias and enhanced emotional well-being. These changes have been termed the "age-related positivity effect." However, the influence of sleep on these measures has not been investigated in healthy older individuals. The objective of this research is to understand the role of sleep in emotional memory consolidation and emotional well-being across adulthood. We hypothesize that sleep contributes to the age-related positivity effect in memory and affect. Our alternative hypothesis is that age-related decreases in sleep are responsible for reduced emotional memory processing over healthy aging.

Conditions

  • Sleep
  • Age
  • Emotional Valence

Interventions

BEHAVIORAL

Overnight sleep

Participant sent home to sleep overnight wearing PSG.

BEHAVIORAL

Wake

Participant sent to go about normal daily routine, instructed not to nap, drink caffeine, or engage in strenuous exercise.

Sponsors & Collaborators

  • University of Massachusetts, Amherst

    lead OTHER

Principal Investigators

  • Rebecca Spencer · University of Massachusetts, Amherst

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-12-11
Primary Completion
2020-05-31
Completion
2020-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04141722 on ClinicalTrials.gov