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Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Activity of Beta-receptors in Healthy Volunteers

NCT04137029 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2019-10-23

No results posted yet for this study

Summary

Interventional open-labeled study in parallel groups is aimed to evaluate changes of beta receptors in healthy volunteers under the influence of inhaled metacholine, long-acting anticholinergics and beta-agonists using modified radioligand method.

Conditions

  • Health, Subjective
  • Hyperreactivity, Bronchial

Interventions

DRUG

Formoterol

The participants will receive inhalation of formoterol 12 micrograms

DRUG

Tiotropium Bromide

The participants will receive inhalation of tiotropium bromide 18 mkg once

DIAGNOSTIC_TEST

metacholine test

The participants will receive inhalation of metacholine once

Sponsors & Collaborators

  • Moscow State University of Medicine and Dentistry

    collaborator OTHER

  • National Medical Research Center for Cardiology, Ministry of Health of Russian Federation

    collaborator OTHER_GOV

  • Branch of Shemyakin-Ovchinnikov Institute of Bioorganic chemistry of RAS

    collaborator UNKNOWN

  • Federal State Budgetary Institution, Pulmonology Scientific Research Institute

    lead OTHER_GOV

Principal Investigators

  • Kirill A Zykov, Prof · Federal State Budgetary Institution, Pulmonology Scientific Research Institute

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-04-24
Primary Completion
2020-07-31
Completion
2020-10-31

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04137029 on ClinicalTrials.gov