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Plasma Oxalate in Patient With Short Bowel

NCT04119765 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 47

Last updated 2022-07-21

No results posted yet for this study

Summary

Hyperoxaluria due to fat malabsorption is seen in patients suffering from short bowel and can lead to stones and nephrocalcinosis. Not all patients are prone to these renal complications. only urinary oxaluria is measured in practice. Plasma oxalate shouldn't increase theoretically in these patients. However recent report showed an increase of plasma oxalate in patient with enteric hyperoxaluria. The aim of this study is to assess the plasma oxalate distribution in this specific population to have a new tool to predict renal complication of these patients.

Conditions

  • Short Bowel Syndrome
  • Hyperoxaluria
  • Hyperoxalemia

Interventions

BIOLOGICAL

Blood sampling

blood sampling will be used to perform oxalemia and FGF23 quantitative analysis

BIOLOGICAL

Urine sampling

urine sampling will be used to measure glycolate urinary rate (glycolaturia) and to perform urinary inflammation markers quantitative analysis

PROCEDURE

Pulse Wave Velocity (PWV) measurement

PWV will be measured thank to the Complior® device

PROCEDURE

central pressure measurement

central pressure will be measured thank to the Complior® device

Sponsors & Collaborators

  • Hospices Civils de Lyon

    lead OTHER

Principal Investigators

  • Sandrine Lemoine, MD · Hospices Civils de Lyon

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-27
Primary Completion
2022-05-04
Completion
2022-05-04

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04119765 on ClinicalTrials.gov