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Phosphodiesterase-5-inhibitors for Right Heart Failure After Left Ventricular Assist Device Implantation

NCT04117659 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2022-06-22

No results posted yet for this study

Summary

Refractory right heart failure is common during the postoperative period after left ventricular assist device implantation. Oral phosphodiesterase-5 inhibitors are oft initiated in order to facilitate weaning from the intravenous inotropic substances. following this period many patients continue to receive the same medication in the long term, despite missing data on its therapeutic effect on right ventricular function.We hypothesise that beyond the acute postoperative period no additional benefit from the phosphodiesterase-5 inhibitors exists. The aim of the study is a detailed clinical and echocardiographic assessment of the right ventricular function after discontinuation of the medication in patients pretreated for at least one month after receiving left ventricular assist device.

Conditions

  • Phosphodiesterase Inhibitor Adverse Reaction
  • Right-Sided Heart Failure

Interventions

OTHER

withdrawal of oral medication (phosphodiesterase-5 inhibitor) in pretreated patients

discontinuation of the oral medication with a phosphodiesterase-5 inhibitor

Sponsors & Collaborators

  • University Hospital, Essen

    lead OTHER

Principal Investigators

  • Maria Papathanasiou, MD · University Hospital, Essen

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-10-15
Primary Completion
2021-02-26
Completion
2021-03-15

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04117659 on ClinicalTrials.gov