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Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice

NCT04109859 · Status: UNKNOWN · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2019-10-01

No results posted yet for this study

Summary

Increased production of vasodilating substances such as NO plays an important role in the development of vasoplegic syndrome caused by obstructive jaundice.Methylene blue plays a role in raising blood pressure by inhibiting the vasodilator Nitric Oxide (NO)

Conditions

  • Jaundice

Interventions

DRUG

Saline

When using saline, if found mean arterial pressure \<65mmHg, Cardic Output\>4L/min, Sequential Vascular Response\<800 (dyne×sec)/cm, starting dose of norepinephrine 0.04ug/min/kg

DRUG

Methylene Blue

Patients in the methylene blue group were given methylene blue before anesthesia and continued intraoperative pumping

Sponsors & Collaborators

  • Jiaolin Ning,MD

    lead OTHER

Principal Investigators

  • Jiaolin Ning, MD · Professor of department of anesthesia, Southwest Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-04-01
Primary Completion
2021-01-21
Completion
2021-01-21

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04109859 on ClinicalTrials.gov