MedTrace Logo

Looking at Cognitive and Brain Changes in People With Lymphoma Receiving CAR-T Therapy

NCT04107285 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2025-10-24

No results posted yet for this study

Summary

The purpose of this study is to learn about possible changes in cognitive (mental) abilities, such as memory skills and concentration, and in brain anatomy (structure) and function, in people with lymphoma receiving CAR-T therapy.

Conditions

  • Lymphoma Receiving CAR-T Therapy

Interventions

BEHAVIORAL

neurocognitive evaluations

The test battery consists of validated and reliable measures of attention, executive functions and memory.

DIAGNOSTIC_TEST

brain MRIs

Patients will undergo baseline and follow-up research MRIs in the same scanner at MSKCC (3 Tesla scanner (GE, Discovery 750W, USA) with a GEM HNU 24-channel head coil) (total scan duration=15 minutes).

OTHER

Blood samples

Research blood samples will be collected pre-CAR T infusion; day of CART infusion (day 0), and post-infusion days 7, 14, 21, 28 (+/- 7 days), at start of neurotoxicity, and at 3-4 months and 6-7 months post-CART.

Sponsors & Collaborators

Principal Investigators

  • Bianca Santomasso, MD, PhD · Memorial Sloan Kettering Cancer Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-09-25
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04107285 on ClinicalTrials.gov