Trial Outcomes & Findings for A Dyadic Approach for a Remote Physical Activity Intervention in Adults With AD and Their Caregivers (NCT NCT04102514)
NCT ID: NCT04102514
Last Updated: 2025-06-08
Results Overview
Moderate physical activity will be assessed using an ActiGraph model wGT3x-BT triaxial at baseline, 3, 6, 12 and 18 months. The ActiGraph wGT3x-BT is worn on a belt on the non-dominant hip during all waking hours for one week (7 consecutive days), with the exception of bathing, and swimming. The device measures acceleration. The acceleration values are used to determine levels of physical activity using previously validated cutpoints. Data were considered valid if they wore the accelerometer for at least 8 hours on 3 days, including 1 weekend day.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
198 participants
Primary outcome timeframe
Baseline to 18 months
Results posted on
2025-06-08
Participant Flow
Participant milestones
| Measure |
Real-time Group Video: Alzheimer's Patient
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Overall Study
STARTED
|
57
|
57
|
42
|
42
|
|
Overall Study
COMPLETED
|
41
|
44
|
27
|
28
|
|
Overall Study
NOT COMPLETED
|
16
|
13
|
15
|
14
|
Reasons for withdrawal
| Measure |
Real-time Group Video: Alzheimer's Patient
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Overall Study
Death
|
3
|
0
|
0
|
0
|
|
Overall Study
Lost to Follow-up
|
0
|
0
|
3
|
0
|
|
Overall Study
Physician Decision
|
0
|
0
|
1
|
0
|
|
Overall Study
Withdrawal by Subject
|
7
|
13
|
7
|
14
|
|
Overall Study
Moved to longterm care facility
|
6
|
0
|
4
|
0
|
Baseline Characteristics
A Dyadic Approach for a Remote Physical Activity Intervention in Adults With AD and Their Caregivers
Baseline characteristics by cohort
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=57 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
n=42 Participants
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
n=42 Participants
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Total
n=198 Participants
Total of all reporting groups
|
|---|---|---|---|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=31 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
9 Participants
n=99 Participants
|
16 Participants
n=107 Participants
|
4 Participants
n=206 Participants
|
9 Participants
n=7 Participants
|
38 Participants
n=31 Participants
|
|
Age, Categorical
>=65 years
|
48 Participants
n=99 Participants
|
41 Participants
n=107 Participants
|
38 Participants
n=206 Participants
|
33 Participants
n=7 Participants
|
160 Participants
n=31 Participants
|
|
Age, Continuous
|
72.0 years
STANDARD_DEVIATION 8.0 • n=99 Participants
|
68.5 years
STANDARD_DEVIATION 11.8 • n=107 Participants
|
75.8 years
STANDARD_DEVIATION 8.6 • n=206 Participants
|
69.7 years
STANDARD_DEVIATION 12.1 • n=7 Participants
|
73.5 years
STANDARD_DEVIATION 8.5 • n=31 Participants
|
|
Sex: Female, Male
Female
|
23 Participants
n=99 Participants
|
38 Participants
n=107 Participants
|
16 Participants
n=206 Participants
|
31 Participants
n=7 Participants
|
108 Participants
n=31 Participants
|
|
Sex: Female, Male
Male
|
34 Participants
n=99 Participants
|
19 Participants
n=107 Participants
|
26 Participants
n=206 Participants
|
11 Participants
n=7 Participants
|
90 Participants
n=31 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
1 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
3 Participants
n=206 Participants
|
4 Participants
n=7 Participants
|
9 Participants
n=31 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
56 Participants
n=99 Participants
|
56 Participants
n=107 Participants
|
39 Participants
n=206 Participants
|
38 Participants
n=7 Participants
|
189 Participants
n=31 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=31 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=31 Participants
|
|
Race (NIH/OMB)
Asian
|
1 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
0 Participants
n=7 Participants
|
2 Participants
n=31 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=31 Participants
|
|
Race (NIH/OMB)
Black or African American
|
2 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
1 Participants
n=7 Participants
|
7 Participants
n=31 Participants
|
|
Race (NIH/OMB)
White
|
53 Participants
n=99 Participants
|
53 Participants
n=107 Participants
|
40 Participants
n=206 Participants
|
40 Participants
n=7 Participants
|
186 Participants
n=31 Participants
|
|
Race (NIH/OMB)
More than one race
|
1 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
1 Participants
n=7 Participants
|
3 Participants
n=31 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=31 Participants
|
|
Region of Enrollment
United States
|
57 participants
n=99 Participants
|
57 participants
n=107 Participants
|
42 participants
n=206 Participants
|
42 participants
n=7 Participants
|
198 participants
n=31 Participants
|
PRIMARY outcome
Timeframe: Baseline to 18 monthsPopulation: Overall number of participants differs from Number analyzed below due to patients and caregivers not meeting wear-time criteria for valid data. Only those with valid wear-time were included in analysis. Additionally, participant/caregiver withdrawal resulted in differing numbers.
Moderate physical activity will be assessed using an ActiGraph model wGT3x-BT triaxial at baseline, 3, 6, 12 and 18 months. The ActiGraph wGT3x-BT is worn on a belt on the non-dominant hip during all waking hours for one week (7 consecutive days), with the exception of bathing, and swimming. The device measures acceleration. The acceleration values are used to determine levels of physical activity using previously validated cutpoints. Data were considered valid if they wore the accelerometer for at least 8 hours on 3 days, including 1 weekend day.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=57 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
n=42 Participants
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
n=42 Participants
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Moderate Physical Activity
Baseline Moderate Physical Activity
|
13.3 minutes per day
Standard Deviation 13.2
|
20.7 minutes per day
Standard Deviation 17.5
|
14.4 minutes per day
Standard Deviation 17.3
|
19.3 minutes per day
Standard Deviation 19.5
|
|
Moderate Physical Activity
Month 3 Moderate Physical Activity
|
14.7 minutes per day
Standard Deviation 16.5
|
25.1 minutes per day
Standard Deviation 23.2
|
11.7 minutes per day
Standard Deviation 14.2
|
23.7 minutes per day
Standard Deviation 21.9
|
|
Moderate Physical Activity
Month 6 Moderate Physical Activity
|
11.6 minutes per day
Standard Deviation 12.9
|
22.6 minutes per day
Standard Deviation 21.1
|
14.1 minutes per day
Standard Deviation 17.7
|
21.1 minutes per day
Standard Deviation 21.5
|
|
Moderate Physical Activity
Month 12 Moderate Physical Activity
|
10.8 minutes per day
Standard Deviation 15.1
|
23.6 minutes per day
Standard Deviation 23.5
|
12.5 minutes per day
Standard Deviation 15.1
|
19.4 minutes per day
Standard Deviation 15.2
|
|
Moderate Physical Activity
Month 18 Moderate Physical Activity
|
12.6 minutes per day
Standard Deviation 18.4
|
20.9 minutes per day
Standard Deviation 22.7
|
16.1 minutes per day
Standard Deviation 18.5
|
29.6 minutes per day
Standard Deviation 21.9
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsPopulation: Overall number of participants differs from Number analyzed below due to patients not meeting wear-time criteria for valid data. Only those with valid wear-time were included in analysis. Additionally, participant withdrawal resulted in differing numbers. This measure is for sedentary time of patients, only. Caregiver sedentary time can be found in secondary outcome 8.
Sedentary time will be assessed using an ActiGraph model wGT3x-BT triaxial at baseline, 6, 12 and 18 months.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Sedentary Time
Month 12 Sedentary Time
|
554.8 minutes per day
Standard Deviation 122.1
|
647.3 minutes per day
Standard Deviation 355.1
|
—
|
—
|
|
Sedentary Time
Baseline Sedentary Time
|
524.8 minutes per day
Standard Deviation 143.3
|
590.1 minutes per day
Standard Deviation 158.7
|
—
|
—
|
|
Sedentary Time
Month 3 Sedentary Time
|
532.1 minutes per day
Standard Deviation 150.6
|
577.2 minutes per day
Standard Deviation 175.6
|
—
|
—
|
|
Sedentary Time
Month 6 Sedentary Time
|
552.5 minutes per day
Standard Deviation 129.5
|
601.4 minutes per day
Standard Deviation 137.0
|
—
|
—
|
|
Sedentary Time
Month 18 Sedentary Time
|
546.8 minutes per day
Standard Deviation 108.6
|
521.9 minutes per day
Standard Deviation 109.6
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsPopulation: Number Analyzed differs from baseline at subsequent timepoints due to participant drops and missed data collection.
Functional fitness will be measured at baseline, 6, 12 and 18 months using Functional Fitness Test (FFT) previously called the Senior Fitness Test. The individual fitness test items involve common activities such as getting up from a chair, walking, lifting, bending, and stretching.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Functional Fitness
Baseline Step Test
|
66.8 Repetitions
Standard Deviation 28.4
|
59.4 Repetitions
Standard Deviation 21.9
|
—
|
—
|
|
Functional Fitness
6 Month Step Test
|
76.9 Repetitions
Standard Deviation 28.3
|
62.2 Repetitions
Standard Deviation 20.3
|
—
|
—
|
|
Functional Fitness
12 Month Step Test
|
74.9 Repetitions
Standard Deviation 28.9
|
66.7 Repetitions
Standard Deviation 19.5
|
—
|
—
|
|
Functional Fitness
18 Month Step Test
|
73.3 Repetitions
Standard Deviation 25.6
|
73.3 Repetitions
Standard Deviation 17.5
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsPopulation: Number Analyzed differs from overall analyzed due to participant drops and non-returned data.
Activities of daily living will be assessed at baseline, 6, 12 and 18 months using the Disabilities Assessment for Dementia (DAD). The DAD includes 40 items: 17 related to basic self-care and 23 to instrumental activities of daily living. Scores range from 0-40, with higher scores indicating less disability.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Activities of Daily Living
Baseline Activities of Daily Living
|
34.0 score on a scale
Standard Deviation 8.8
|
30.8 score on a scale
Standard Deviation 12.4
|
—
|
—
|
|
Activities of Daily Living
6 Month Activities of Daily Living
|
31.3 score on a scale
Standard Deviation 11.8
|
28.7 score on a scale
Standard Deviation 11.6
|
—
|
—
|
|
Activities of Daily Living
12 Month Activities of Daily Living
|
28.2 score on a scale
Standard Deviation 12.4
|
29.3 score on a scale
Standard Deviation 10.2
|
—
|
—
|
|
Activities of Daily Living
18 Month Activities of Daily Living
|
29.0 score on a scale
Standard Deviation 14.7
|
32.7 score on a scale
Standard Deviation 12.8
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsPopulation: Number analyzed differs from overall participants due to participant drops and non-returned surveys. Measure only pertained to Alzheimer's Patient.
Quality of life will be assessed at baseline to 18 months using the QOL-AD, a brief, 13-item self-report and 15-item caregiver-report. Each item is rated on a scale from 1-4, 1=Poor, 2=Fair, 3=Good, 4=Excellent. Scores range from 13-52, with larger numbers indicating better quality of life.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Change in Quality of Life
Baseline Quality of Life
|
37.59 Score on a scale
Standard Deviation 4.92
|
38.61 Score on a scale
Standard Deviation 5.03
|
—
|
—
|
|
Change in Quality of Life
6 Month Quality of Life
|
38.83 Score on a scale
Standard Deviation 5.78
|
38.75 Score on a scale
Standard Deviation 4.29
|
—
|
—
|
|
Change in Quality of Life
12 Month Quality of Life
|
37.93 Score on a scale
Standard Deviation 5.09
|
38.81 Score on a scale
Standard Deviation 4.94
|
—
|
—
|
|
Change in Quality of Life
18 Month Quality of Life
|
36.71 Score on a scale
Standard Deviation 5.06
|
38.30 Score on a scale
Standard Deviation 3.82
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsResidential transitions, i.e., from home to institutional care, will be tracked by health coaches. Caregiver desire to institutionalize the adult with AD will be assessed using the 6-item Morycz's Desire-to-Institutionalize Scale
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Residential Transitions
6 Month Transitions
|
0 Participants
|
0 Participants
|
—
|
—
|
|
Residential Transitions
12 Month Transitions
|
2 Participants
|
3 Participants
|
—
|
—
|
|
Residential Transitions
18 Month Transitions
|
5 Participants
|
3 Participants
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsPopulation: Number analyzed below differs from overall due to participant drops and non-returned data.
Cognitive function will be assessed at baseline, 6, 12 and 18 months using Applied Cognition Abilities 4a instruments from the Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive Function Battery. Both test contain 4 questions that will be answered by the adult with AD. Scores range from 0-100, with higher scores indicating better cognitive function.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Cognitive Function
Baseline Cognitive Function
|
38.6 score on a scale
Standard Deviation 13.9
|
41.9 score on a scale
Standard Deviation 10.1
|
—
|
—
|
|
Cognitive Function
6 Month Cognitive Function
|
27.3 score on a scale
Standard Deviation 19.1
|
34.7 score on a scale
Standard Deviation 16.8
|
—
|
—
|
|
Cognitive Function
12 Month Cognitive Function
|
31.8 score on a scale
Standard Deviation 22.2
|
34.9 score on a scale
Standard Deviation 18.5
|
—
|
—
|
|
Cognitive Function
18 Month Cognitive Function
|
24.8 score on a scale
Standard Deviation 21.9
|
32.2 score on a scale
Standard Deviation 19.2
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsPopulation: Overall number of participants differs from Number analyzed below due to patients and caregivers not meeting wear-time criteria for valid data. Only those with valid wear-time were included in analysis. Additionally, participant/caregiver withdrawal resulted in differing numbers.
Caregiver sedentary time will be assessed using an ActiGraph model wGT3x-BT triaxial at baseline, 6, 12 and 18 months.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Caregiver Sedentary Time
18 Month Sedentary Time
|
517.9 minutes per day
Standard Deviation 109.6
|
571.2 minutes per day
Standard Deviation 386.7
|
—
|
—
|
|
Caregiver Sedentary Time
Baseline Sedentary Time
|
525.1 minutes per day
Standard Deviation 143.7
|
526.9 minutes per day
Standard Deviation 123.7
|
—
|
—
|
|
Caregiver Sedentary Time
6 Month Sedentary Time
|
518.7 minutes per day
Standard Deviation 131.4
|
526.0 minutes per day
Standard Deviation 141.2
|
—
|
—
|
|
Caregiver Sedentary Time
12 Month Sedentary Time
|
521.2 minutes per day
Standard Deviation 116.9
|
542.1 minutes per day
Standard Deviation 138.9
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsPopulation: Number Analyzed differs from baseline at subsequent timepoints due to participant drops and missed data collection.
Caregiver functional fitness will be measured at baseline, 6, 12 and 18 months using Functional Fitness Test (FFT) previously called the Senior Fitness Test. The individual fitness test items involve common activities such as getting up from a chair, walking, lifting, bending, and stretching.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Caregiver Functional Fitness
Baseline Step Test
|
80.2 Reptetitions
Standard Deviation 22.0
|
80.0 Reptetitions
Standard Deviation 20.5
|
—
|
—
|
|
Caregiver Functional Fitness
6 Month Step Test
|
94.7 Reptetitions
Standard Deviation 25.8
|
84.3 Reptetitions
Standard Deviation 19.4
|
—
|
—
|
|
Caregiver Functional Fitness
12 Month Step Test
|
93.9 Reptetitions
Standard Deviation 28.7
|
87.1 Reptetitions
Standard Deviation 20.3
|
—
|
—
|
|
Caregiver Functional Fitness
18 Month Step Test
|
96.4 Reptetitions
Standard Deviation 25.7
|
92.4 Reptetitions
Standard Deviation 22.1
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsPopulation: Number analyzed below differs from overall number due to participant drops and non-returned data. Measure only collected from Caregivers.
Caregiver quality of life will be assessed at baseline, 6, 12 and 18 months using the SF-36, which involves 36 questions relating to quality of life in typically developed adults. Scores range from 0-100, with higher score indicates better health.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Caregiver Quality of Life
Baseline Caregiver Quality of Life
|
36.4 score on a scale
Standard Deviation 5.8
|
37.0 score on a scale
Standard Deviation 7.4
|
—
|
—
|
|
Caregiver Quality of Life
6 Month Caregiver Quality of Life
|
36.4 score on a scale
Standard Deviation 7.1
|
36.3 score on a scale
Standard Deviation 6.0
|
—
|
—
|
|
Caregiver Quality of Life
12 Month Caregiver Quality of Life
|
36.6 score on a scale
Standard Deviation 6.5
|
37.9 score on a scale
Standard Deviation 6.8
|
—
|
—
|
|
Caregiver Quality of Life
18 Month Caregiver Quality of Life
|
34.1 score on a scale
Standard Deviation 6.0
|
38.1 score on a scale
Standard Deviation 7.7
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline to 18 monthsPopulation: Number analyzed differs from overall due to participant drops and non-returned data. Measure was collected from Caregivers only.
Caregiver Burden will be assessed at baseline, 6, 12 and 18 months using the Zarit Burden Interview-short version, a 12-item self-report questionnaire in which the caregiver is asked to answer using a 5-point scale. Scores range from 0-48, with lower scores indicating less caregiver burden.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Caregiver Burden
Baseline Caregiver Burden
|
1.75 score on a scale
Standard Deviation 0.94
|
1.49 score on a scale
Standard Deviation 1.02
|
—
|
—
|
|
Caregiver Burden
6 Month Caregiver Burden
|
1.5 score on a scale
Standard Deviation 0.97
|
1.53 score on a scale
Standard Deviation 0.86
|
—
|
—
|
|
Caregiver Burden
12 Month Caregiver Burden
|
1.53 score on a scale
Standard Deviation 0.97
|
1.52 score on a scale
Standard Deviation 0.95
|
—
|
—
|
|
Caregiver Burden
18 Month Caregiver Burden
|
1.93 score on a scale
Standard Deviation 1.07
|
1.28 score on a scale
Standard Deviation 1.02
|
—
|
—
|
OTHER_PRE_SPECIFIED outcome
Timeframe: Baseline to 18 monthsPopulation: Number analyzed below differs from overall number due to participant drops and missed data collection.
Weight will be measured in duplicate at baseline, 6, 12 and 18 months in light clothing on a calibrated scale (Model #PS6600, Belfour, Saukville, WI) to the nearest 0.1 kg. Standing height will be measured at baseline, 6, 12 and 18 months in duplicate with a portable stadiometer (Model #IP0955, Invicta Plastics Limited, Leicester, UK). BMI will be calculated as weight (kg)/height (m2).
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=57 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
n=42 Participants
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
n=42 Participants
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Body Mass Index
Baseline Body Mass Index
|
26.8 kg/m2
Standard Deviation 4.6
|
28.4 kg/m2
Standard Deviation 6.4
|
26.9 kg/m2
Standard Deviation 5.3
|
29.5 kg/m2
Standard Deviation 6.0
|
|
Body Mass Index
6 Month Body Mass Index
|
26.5 kg/m2
Standard Deviation 4.4
|
29.0 kg/m2
Standard Deviation 6.7
|
26.7 kg/m2
Standard Deviation 5.1
|
29.7 kg/m2
Standard Deviation 6.3
|
|
Body Mass Index
12 Month Body Mass Index
|
26.7 kg/m2
Standard Deviation 4.6
|
29.1 kg/m2
Standard Deviation 6.6
|
26.3 kg/m2
Standard Deviation 4.9
|
29.3 kg/m2
Standard Deviation 6.3
|
|
Body Mass Index
18 Month Body Mass Index
|
26.0 kg/m2
Standard Deviation 3.6
|
28.8 kg/m2
Standard Deviation 7.1
|
27.1 kg/m2
Standard Deviation 5.0
|
28.8 kg/m2
Standard Deviation 7.1
|
OTHER_PRE_SPECIFIED outcome
Timeframe: Baseline to 18 monthsPopulation: Number analyzed below differs from overall number due to participant drops. Measure only collected in Real-time Group Video arm.
Session attendance for group exercise (RGV only) and support sessions will be obtained from records maintained by the health coach, and expressed as the percent of possible sessions from 0-6 mos. and 7-12 mos. Attendance for adults with AD, enrolled caregivers, and alternative caregivers will be recorded separately.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=57 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Session Attendance
Baseline to 6 Months
|
74.0 percent of possible sessions
Standard Deviation 31.3
|
69.5 percent of possible sessions
Standard Deviation 33.0
|
—
|
—
|
|
Session Attendance
Month 7 to Month 12
|
75.7 percent of possible sessions
Standard Deviation 46.0
|
71.0 percent of possible sessions
Standard Deviation 48.0
|
—
|
—
|
OTHER_PRE_SPECIFIED outcome
Timeframe: Baseline to 18 monthsUse of recorded videos including frequency and duration of access (RGV only) will be assessed using Dropbox® analytics.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=57 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Use of Recorded Videos
|
0.17 Video views per week
Standard Deviation 0.70
|
0.17 Video views per week
Standard Deviation 0.70
|
—
|
—
|
OTHER_PRE_SPECIFIED outcome
Timeframe: Baseline to 18 monthsSelf-monitoring of physical activity will be assessed as the percentage of days with Fitbit data over a minimum of 8 hrs., between 6 am and midnight
Outcome measures
Outcome data not reported
OTHER_PRE_SPECIFIED outcome
Timeframe: Baseline to 18 monthsCaregiver support will be assessed using the percentage of group exercise sessions (RGV) and/ or individual support sessions completed by both the person with AD and their caregiver.
Outcome measures
Outcome data not reported
OTHER_PRE_SPECIFIED outcome
Timeframe: Baseline to 18 monthsStaff will review video recordings of a random sample of 33% of group exercise sessions to identify and classify both peer to peer, and health coach to participant interactions. Interactions will be quantified and coded as verbal/non-verbal (waving, pointing, shaking head in agreement/disagreement), and as positive, neutral or negative, relative to support.
Outcome measures
Outcome data not reported
OTHER_PRE_SPECIFIED outcome
Timeframe: Baseline to 18 monthsPopulation: Number analyzed below differs from overall number due to participant drops and non-returned data.
Quality of the dyadic relationship will be assessed at baseline, 6, 12, and 18 mos. using the dyadic relationship scale (DRS) which measures negative and positive dyadic interactions from the perspective of both the patient and the caregiver. Scores range from 1-6, with higher scores indicating more positive dyadic relationships.
Outcome measures
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 Participants
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=42 Participants
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Quality of the Dyadic Relationship
Baseline Quality of the dyadic relationship
|
2.69 score on a scale
Standard Deviation 0.78
|
2.92 score on a scale
Standard Deviation 0.66
|
—
|
—
|
|
Quality of the Dyadic Relationship
6 Month Quality of the dyadic relationship
|
2.71 score on a scale
Standard Deviation 0.71
|
2.90 score on a scale
Standard Deviation 0.55
|
—
|
—
|
|
Quality of the Dyadic Relationship
12 Month Quality of the dyadic relationship
|
2.72 score on a scale
Standard Deviation 0.70
|
2.83 score on a scale
Standard Deviation 0.65
|
—
|
—
|
|
Quality of the Dyadic Relationship
18 Month Quality of the dyadic relationship
|
2.72 score on a scale
Standard Deviation 0.65
|
2.72 score on a scale
Standard Deviation 0.75
|
—
|
—
|
POST_HOC outcome
Timeframe: Baseline to 12 monthsEnergy expenditure of the remote sessions will be assessed using a portable metabolic system.
Outcome measures
Outcome data not reported
Adverse Events
Real-time Group Video: Alzheimer's Patient
Serious events: 9 serious events
Other events: 28 other events
Deaths: 3 deaths
Real-time Group Video: Caregiver
Serious events: 6 serious events
Other events: 23 other events
Deaths: 0 deaths
Enhanced Usual Care: Alzheimer's Patient
Serious events: 7 serious events
Other events: 21 other events
Deaths: 0 deaths
Enhanced Usual Care: Caregiver
Serious events: 1 serious events
Other events: 6 other events
Deaths: 0 deaths
Serious adverse events
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 participants at risk
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=57 participants at risk
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
n=42 participants at risk
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
n=42 participants at risk
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Musculoskeletal and connective tissue disorders
Hospitalization
|
5.3%
3/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
3.5%
2/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Respiratory, thoracic and mediastinal disorders
Hospitalization
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
7.1%
3/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Nervous system disorders
Hospitalization
|
5.3%
3/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Infections and infestations
Hospitalization
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
3.5%
2/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
4.8%
2/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Cardiac disorders
Hospitalization
|
3.5%
2/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Gastrointestinal disorders
Hospitalization
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
Other adverse events
| Measure |
Real-time Group Video: Alzheimer's Patient
n=57 participants at risk
Alzheimer's Patients randomized to the RGV arm were asked to complete three 45 min sessions that include aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Real-time Group Video: Caregiver
n=57 participants at risk
Caregivers of Alzheimer's patients randomized to the Real-time Group Video arm attended three 45 min sessions with the Alzheimer's Patient that included aerobic, resistance, and balance/coordination exercises delivered by a trained health coach via Zoom® software on an iPad during mos. 0-6, and 1 session/wk. during mos. 7-12 to groups of 5-8 dyads in their home along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Alzheimer's Patient
n=42 participants at risk
Alzheimer's Patients in the EUC arm, were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
Enhanced Usual Care: Caregiver
n=42 participants at risk
Caregivers in the EUC arm, assisted the Alzheimer's Patient with increasing MPA and were given a recommended exercise plan to follow on their own along with being provided written materials regarding exercise and physical activity from the National Institute on Aging and brief (15-20 min) FaceTime meetings (0-6 mos.= 2/mo.; 7-12 mos.= 1/mo.) with the heath coach to discuss progress, provide support and receive additional guidance on how to increase MPA.
|
|---|---|---|---|---|
|
Infections and infestations
Bee sting
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Musculoskeletal and connective tissue disorders
Fall
|
14.0%
8/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
3.5%
2/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
28.6%
12/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Infections and infestations
Infection
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
3.5%
2/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Cardiac disorders
Low blood pressure
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Musculoskeletal and connective tissue disorders
Back pain
|
5.3%
3/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
7.0%
4/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
4.8%
2/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Musculoskeletal and connective tissue disorders
Knee pain
|
3.5%
2/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
7.0%
4/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
4.8%
2/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
7.1%
3/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Musculoskeletal and connective tissue disorders
Ankle Pain
|
5.3%
3/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Musculoskeletal and connective tissue disorders
Hip Pain
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
7.0%
4/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Endocrine disorders
Graves Disease Diagnosis
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Nervous system disorders
Seizure
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Eye disorders
Eye surgery
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
3.5%
2/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Skin and subcutaneous tissue disorders
Skin Cancer removal
|
3.5%
2/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Musculoskeletal and connective tissue disorders
Arm surgery
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
3.5%
2/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
2.4%
1/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
General disorders
Respite care
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Gastrointestinal disorders
Choking
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Renal and urinary disorders
Chronic Kidney Disease Flare Up
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Skin and subcutaneous tissue disorders
Stepped on broken glass
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
|
Musculoskeletal and connective tissue disorders
Pelvic Prolapse Surgery
|
1.8%
1/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/57 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
0.00%
0/42 • Data collected over 18 month intervention.
Number of participants at Risk in all categories is combined to include both Alzheimer's Patients and Caregivers.
|
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place