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Epigenetic Changes in Psychotherapy of Adolescents With Borderline Personality Pathology

NCT04095546 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2022-09-13

No results posted yet for this study

Summary

The link between epigenetic changes as an effect of psychotherapy has been investigated recently. Genes investigated in these studies were brain-derived neurotrophic factor (BDNF), NR3C1, FKBP51, MAOA and GLUT1. Change in methylation of these genes could be a biomolecular mechanism of psychotherapy induced changes. This study project aims at providing evidence for a biological mechanism of personality disorder interventions in adolescence by investigating the link between epigenetic changes as an effect of psychotherapy. It investigates the correlation between changes in the methylation of the FKBP5 gene and psychotherapy induced changes in symptoms and functioning.

Conditions

  • Borderline Personality Disorder (BPD)

Interventions

OTHER

routine psychotherapy for Borderline Personality Disorder (BPD)

Routine psychotherapy as treatment for patients with Borderline Personality Disorder

Sponsors & Collaborators

  • Leading House for the Latin American Region (Seed Money Grant SMG 1730)

    collaborator UNKNOWN

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Ronan Zimmermann, PhD · Kinder- und Jugendpsychiatrische Klinik/Universitäre Psychiatrische Klinken Basel (UPK)

Eligibility

Min Age
14 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-30
Primary Completion
2024-02-29
Completion
2024-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04095546 on ClinicalTrials.gov