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Tissue Sodium in Patients With Psoriasis

NCT04095130 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2019-09-19

No results posted yet for this study

Summary

Sodium can be buffered in the skin, which mechanism is altered during aging and in certain diseases such as hypertension. High salt environment can promote autoimmunity by expanding pathogenic IL-17 producing T helper (Th17) cells. Psoriasis is a relapsing and remitting inflammatory autoimmune disease affecting the skin and joints and involves proinflammatory Th17 cells. Here we tested the hypothesis if psoriatic skin has a higher sodium content in humans.

Conditions

  • Psoriasis Vulgaris
  • Healthy

Interventions

DIAGNOSTIC_TEST

23Na Magnetic resonance imaging

Measurement of skin sodium content by non-invasive 23Na Magnetic resonance imaging.

Sponsors & Collaborators

  • German Heart Center

    collaborator OTHER

  • Charite University, Berlin, Germany

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-07-01
Primary Completion
2018-03-16
Completion
2019-09-17

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04095130 on ClinicalTrials.gov