Efficacy of Short Pulsed 1064 nm Nd-YAG Laser Versus 10600 nm Fractional CO2 Laser in Treatment of Striae Alba

Summary

Striae alba is a clinical variant of striae distensae characterized by focal dermal collagen loss and thinning of elastic fibers. Carbon dioxide (CO2) laser is an ablative laser modality that ablates defective collagen and stimulates new collagen formation. Neodymium-Doped Yttrium Aluminum Garnet (Nd-YAG) laser is a non ablative modality that results in stimulation of collagen formation through dermal heating. High frequency skin ultrasound is a rapid and non-invasive tool for measurement f skin thickness and can be used for this purpose.

Conditions

• Striae Distensae
• Striae; Albicantes
• Striae Alba
• Nd-YAG Laser
• Fractional CO2 Laser
• High Frequency Skin Ultrasound
• Short Pulsed Nd-YAG
• Carbon Dioxide Laser
• Neodymium-Doped Yttrium Aluminum Garnet Laser

Interventions

DEVICE

Laser

Application of four laser sessions one month apart using short pulsed mode of 1064 nm Nd-YAG laser (Fotona XP® - Accelera mode) using parameters (fluence 20-40 J/Cm2, pulse duration= 0.25 ms and spot size 3-5 mm) for one side.

DEVICE

Laser

Application of four laser sessions one month apart (in the same day after Nd-YAG session) using 10600 nm ablative fractional CO2 laser (Deka SmartXide DOT®) using -parameters (fluence 17-20 J/Cm2, pulse duration 700-1000 µs, spacing 600-700 µm and stacking 1-2) on the other. Sessions are separated by one month interval plus three months for clinical follow up.

Sponsors & Collaborators

• Cairo University

  lead OTHER

Principal Investigators

• Heba Abd El-Kader, MD · Lecturer of Dermatology, Cairo University

• Manal A. Bosseila, MD · Professor of Dermatology, Cairo University

• Khaled El Kaffas, MD · Associate Professor of Investigative Radiology, Department of Radiology, Cairo University

• Omar M. El-Ghanam, MSc · Dermatology Specialist

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

14 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-02-01

Primary Completion

2021-10-01

Completion

2021-12-31

FDA Device

Yes

Countries

• Egypt

Study Locations