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Pulmonary Epithelium, Immunology and Development of Asthma: Breathing Together

NCT04063631 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1300

Last updated 2024-01-09

No results posted yet for this study

Summary

The investigators want to know why some babies wheeze and some of these go on to develop asthma. The investigators are going to find out if babies who develop wheeze and asthma have abnormal airway lining cells (taken from the nose) when they are born and what happens to these cells as they get older.

The study will last three years. Parents will be asked to fill in a monthly health questionnaire. The tests on the babies are all in routine clinical use: a urine sample, a blood test from a heel or finger prick, swabs from the nose and throat to look at the microbiome, and a brushing of cells from the inside of the nose. These tests will be performed at 5-10 days old, and at one and three years. Parents will be asked to fill in online monthly health questionnaire. Some babies will have the swabs repeated at 3 and 6 months, and those who wheeze in the first 3 years of life, samples during the illness and after recovery.

Conditions

Sponsors & Collaborators

  • Queen Mary University of London

    collaborator OTHER

  • University of Bristol

    collaborator OTHER

  • University of Southampton

    collaborator OTHER

  • University of Edinburgh

    collaborator OTHER

  • Queen's University, Belfast

    collaborator OTHER

  • University of Aberdeen

    collaborator OTHER

  • Monash University

    collaborator OTHER

  • Imperial College London

    lead OTHER

Principal Investigators

  • Andrew Bush, MD · Imperial College London

Eligibility

Min Age
5 Days
Max Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-02-20
Primary Completion
2024-09-18
Completion
2024-09-18

Countries

  • United Kingdom

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04063631 on ClinicalTrials.gov