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Hemodynamic Effects of BPA at Rest and During Exercise in CTEPH

NCT04052243 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2022-07-20

No results posted yet for this study

Summary

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by obstruction of the pulmonary vasculature by residual organized thrombi, leading to increased pulmonary vascular resistance (PVR), progressive pulmonary hypertension, and right heart failure.

Medical therapy and balloon angioplasty (BPA) are effective treatment alternatives in lowering pulmonary pressures and increasing pulmonary flow.

The aim of this study is to assess the hemodynamic effects of BPA or medical therapy on the pressure-flow relationship in the pulmonary vasculature and the pulmonary vascular compliance.

Conditions

  • Chronic Thromboembolic Pulmonary Hypertension

Interventions

DIAGNOSTIC_TEST

Invasive exercise testing

Invasive hemodynamic exercise testing

Sponsors & Collaborators

  • Nagoya University

    collaborator OTHER

  • Department of Pulmonary Circulation and Thromboembolic Diseases, Medical Center for Postgraduate Med

    collaborator OTHER

  • Aarhus University Hospital

    lead OTHER

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2023-12-31
Completion
2024-06-30

Countries

  • Denmark
  • Japan
  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04052243 on ClinicalTrials.gov