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Modelling the Interaction Between Synthetic Model Immunogens and the Induced B and T Cell Repertoires.

NCT04046978 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2023-08-22

No results posted yet for this study

Summary

MOSAIC is a single-blind experimental medicine study to determine the extent to which different prime-boost combinations of model immunogens based on HIV-1 envelope proteins influence the diversity of B and T cell responses.

Conditions

  • Virus Diseases

Interventions

OTHER

ConM SOSIP 50 ug and ConS UFO 50 ug

Intramuscular injection of synthetic viral immunogens ConM SOSIP and ConS UFO

OTHER

Mos3.1 100 ug

Intramuscular injection of synthetic viral immunogen Mos3.1

OTHER

Mos3.2 100 ug

Intramuscular injection of synthetic viral immunogen Mos3.2

OTHER

Mos3.3 100 ug

Intramuscular injection of synthetic viral immunogen Mos3.3

OTHER

Mos3.1 33 ug, Mos3.2 33 ug and Mos3.3 33 ug

Intramuscular injection of synthetic viral immunogens Mos3.1, Mos3.2 and Mos3.3

Sponsors & Collaborators

Principal Investigators

  • Katrina Pollock, MD · Imperial College London

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-12-11
Primary Completion
2022-12-31
Completion
2022-12-31

Countries

  • United Kingdom

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04046978 on ClinicalTrials.gov