CD147-CART Cells in Patients With Recurrent Malignant Glioma.
NCT04045847 · Status: UNKNOWN · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 31
Last updated 2020-05-07
Summary
This is a single-center, single-arm, open label and dose escalation clinical study of anti-CD147 CART cells in patients with recurrent malignant glioma.
Conditions
- Recurrent Glioblastoma
- CD147 Positive
Interventions
- BIOLOGICAL
-
CD147-CART
Three doses of CD147-CART cells were injection to intracavity by Ommaya Reservoir.
Sponsors & Collaborators
-
Xijing Hospital
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-05-30
- Primary Completion
- 2020-10-30
- Completion
- 2022-05-30
Countries
- China
Study Locations
More Related Trials
-
Pilot Study of Autologous Anti-EGFRvIII CAR T Cells in Recurrent Glioblastoma Multiforme
NCT02844062 ·Status: UNKNOWN ·Phase: PHASE1
-
Exablate Blood-Brain Barrier Disruption for the Treatment of rGBM in Subjects Undergoing Carboplatin Monotherapy
NCT04417088 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Neoadjuvant Carilizumab and Apatinib for Recurrent High-Grade Glioma
NCT04588987 ·Status: UNKNOWN ·Phase: PHASE2
-
CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients
NCT04406610 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Allogeneic γδT Cells in Glioblastoma
NCT07144735 ·Status: RECRUITING ·Phase: NA
-
Clinical Study of Oncolytic Virus in Glioblastoma
NCT07145047 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
The Safety and Efficacy of SNC-109 CAR-T Cells Therapy the rGBM
NCT06616727 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE1
-
GDC-0449 in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery
NCT00980343 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate the Safety, Tolerance and Initial Efficacy of EGFRvIII CAR-T on Glioblastoma
NCT05802693 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Effect of NovoTTF-100A in Recurrent Glioblastoma Multiforme (GBM)
NCT00379470 ·Status: COMPLETED ·Phase: PHASE3
-
B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme
NCT05474378 ·Status: RECRUITING ·Phase: PHASE1
-
Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Newly Diagnosed Malignant Glioma
NCT01656980 ·Status: UNKNOWN ·Phase: PHASE3
-
Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Recurrent Malignant Glioma
NCT01637753 ·Status: UNKNOWN ·Phase: NA
-
A Study of DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma
NCT04458272 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Pilot Study of Autologous Chimeric Switch Receptor Modified T Cells in Recurrent Glioblastoma Multiforme
NCT02937844 ·Status: UNKNOWN ·Phase: PHASE1
-
Glufosfamide in Treating Patients With Recurrent Glioblastoma Multiforme
NCT00014300 ·Status: COMPLETED ·Phase: PHASE2
-
A Study on β-elemene as Maintain Treatment for Newly Diagnosed Malignant Gliomas
NCT02629757 ·Status: UNKNOWN ·Phase: PHASE3
-
Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme
NCT03170141 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE1
-
BC008-1A Injection for Recurrent CNS WHO G4 Glioma
NCT06773481 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of BL-B01D1 in Patients With Recurrent Glioblastoma
NCT06598787 ·Status: RECRUITING ·Phase: PHASE2
-
Ketogenic Diet Adjunctive to Salvage Chemotherapy for Recurrent Glioblastoma:a Pilot Study
NCT02939378 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of MEDI-575 in Subjects With Recurrent Glioblastoma Multiforme
NCT01268566 ·Status: COMPLETED ·Phase: PHASE2
-
WL276 CAR-T Cell Therapy for CD276 Positive Recurrent or Progressive Glioblastoma Patients
NCT06691308 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma
NCT04977375 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients
NCT02575261 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2