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The Research of Metabolomics on COPD

NCT04042519 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2019-08-02

No results posted yet for this study

Summary

Targeted metabolomics research was conducted on patients with chronic obstructive pulmonary disease (COPD). The correlation analyst between inflammation-related metabolites and lung function was analyzed by explored the metabolic pathways of inflammation-related omega-6 and omega-3 and combining them with lung function.

Conditions

  • Metabolomics
  • Omega 6
  • Omega 3
  • COPD

Interventions

DIAGNOSTIC_TEST

Lung function test was performed on the subjects with Jaeger lung function instrument of Germany.

This Jaeger lung function instrument of Germany is used to test the pulmonary ventilation function of COPD patients. Since the condition requires drug control and treatment, the drug cannot be stopped.

DIAGNOSTIC_TEST

Agilent 1290 Infinity LC system (UHPLC, Santa Clara CA) was used for Targeted metabolite detection.

We used the Agilent 1290 Infinity LC system mass spectrometer to analyze and detect metabolite peaks of patients according to retention time and mass/charge ratio after preliminary experiments and derivatization.

DIAGNOSTIC_TEST

Routine blood test

Blood routine test results include CRP, PCT, white blood cell count, red blood cell count, neutrophil percentage, eosinophil, basophil, et al.

Sponsors & Collaborators

  • The Fifth Affiliated Hospital of Zunyi Medical College

    collaborator OTHER

  • Guangzhou Institute of Respiratory Disease

    lead OTHER

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-10-01
Primary Completion
2018-10-01
Completion
2019-07-05

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04042519 on ClinicalTrials.gov