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Triple H ODC Trial

NCT04041531 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2020-09-09

No results posted yet for this study

Summary

In an avalanche burial with an air pocket hypercapnia (and hypoxia) develops within few minutes, hypercapnia increases the rate of cooling and therefore the development of hypothermia. The Triple H Syndrome (Hypoxia, Hypercapnia, Hypothermia) occurs. This specific combination of the three parameters is unique for avalanche burial with an air pocket. Every single parameter has a substantial effect on the hemoglobin-oxygen dissociation curve, but until now no study described the combination of these three parameters. This curve will be measured under these specific conditions in a specifically developed in vitro model, to quantify its shifts and to show if there are combined effects of pCO2 and temperature. The newly developed method will be validated in comparison with an established method. The project will be performed with whole blood, drawn by healthy volunteers, in an experimental setting. The samples will be blinded to the investigator and analyzed in a randomized manner.

Conditions

  • Hypoxia
  • Hypothermia, Accidental
  • Hypercapnia
  • Avalanche, Landslide, or Mudslide

Interventions

OTHER

blood sampling

venous blood sampling for oxygen affinity in-vitro test

Sponsors & Collaborators

  • Institute of Mountain Emergency Medicine

    collaborator OTHER

  • Medical University Innsbruck

    lead OTHER

Principal Investigators

  • Mathias Ströhle, MD · Medical University Innsbruck

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-08-26
Primary Completion
2019-11-30
Completion
2020-02-10

Countries

  • Austria

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04041531 on ClinicalTrials.gov