A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors
NCT04032704 · Status: TERMINATED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 205
Last updated 2025-03-10
Summary
This trial will study ladiratuzumab vedotin (LV) alone and with pembrolizumab to find out if it works to treat different types of solid tumors. It will also find out what side effects may occur. A side effect is anything the drug does besides treating cancer.
Conditions
- Small Cell Lung Cancer
- Non-small Cell Lung Cancer, Squamous
- Non-small Cell Lung Cancer, Non-squamous
- Head and Neck Squamous Cell Carcinoma
- Esophageal Squamous Cell Carcinoma
- Gastric Adenocarcinoma
- Gastroesophageal Junction Adenocarcinoma
- Prostate Cancer
- Melanoma
Interventions
- DRUG
-
ladiratuzumab vedotin
Intravenous (into the vein; IV) infusion
- DRUG
-
200mg given by IV on Day 1 of each 21-day cycle
Sponsors & Collaborators
- collaborator INDUSTRY
-
Seagen Inc.
lead INDUSTRY
Principal Investigators
-
Pfizer CT.gov Call Center · Pfizer
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-10-09
- Primary Completion
- 2023-11-28
- Completion
- 2023-11-28
- FDA Drug
- Yes
Countries
- United States
- Australia
- Italy
- South Korea
- Taiwan
- United Kingdom
Study Locations
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