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Molecular Analysis of Diabetic Kidney Disease Biopsies

NCT04029402 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2021-04-30

No results posted yet for this study

Summary

Despite decades of research, the pathogenesis of human diabetic kidney disease remains largely unclear. Our goal is to use archived human kidney biopsy tissue from patients with and with diabetic nephropathy to identify new molecules that drive and/or protect against disease progression. We will use RNA sequencing to identify transcriptomic changes that associate with histologic and functional outcomes.

Conditions

  • Diabetic Nephropathies
  • Kidney Disease, Chronic

Interventions

OTHER

RNA sequencing

Transcriptomic analysis of kidney biopsy tissue, and linking with slope of eGFR decline

Sponsors & Collaborators

  • University of Ottawa

    collaborator OTHER

  • University of British Columbia

    collaborator OTHER

  • University of Manitoba

    collaborator OTHER

  • Unity Health Toronto

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-01
Primary Completion
2022-12-31
Completion
2025-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04029402 on ClinicalTrials.gov