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Phenotyping Genetic Risk for Type 2 Diabetes

NCT04024631 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-09-10

No results posted yet for this study

Summary

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

Conditions

  • Diabetes Mellitus, Type 2
  • Genetics

Interventions

OTHER

75g glucose beverage (Glucola, Trutol, or similar brand)

Subjects will present fasting to the study day and ingest the glucose beverage during the oral glucose tolerance test.

OTHER

DXA, whole body

Subjects will undergo a whole body DXA scan for assessment of adiposity index and body fat distribution.

Sponsors & Collaborators

Principal Investigators

  • Jessica R Wilson, MD, MS · University of Pennsylvania

  • Lorraine Levitt Katz, MD · Children's Hospital of Philadelphia

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
10 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-06-17
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04024631 on ClinicalTrials.gov