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Natural History of Hypereosinophilia and Hypereosinophilic Syndromes

NCT04018118 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2026-02-20

No results posted yet for this study

Summary

Unexplained chronic hypereosinophilia (HE) and hypereosinophilic syndromes (HES) are heterogeneous regarding the organ involvements (heart, lungs, skin, .. or none), the evolutionary profiles, the response to treatments.

Underlying mechanisms are largely unknown and may associate genetic predisposing factors (germinal ? somatic?), environmental factors (alimentation, tobacco use, hormones, infections, ..) The COHESion study aims to study all clinical and biological characteristics of HE/HES patients and their evolutionary profiles, with a focus on genetic factors and the mechanisms supporting transitory or persistant chronic HE/HES (in absence of any well identified extrinsic trigger like drugs, parasitosis, ..)

Conditions

  • Eosinophilia
  • Hypereosinophilic Syndrome

Interventions

BIOLOGICAL

Biological sample

Additional blood samples for biobanking

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Guillaume Lefevre · University Hospital, Lille

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-05-06
Primary Completion
2029-05-06
Completion
2031-05-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04018118 on ClinicalTrials.gov